The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
AKAP Signaling Complexes in Regulation of Excitatory Synaptic Plasticity
Open accessAbstract
Plasticity at excitatory glutamatergic synapses in the central nervous system is believed to be critical for neuronal circuits to process and encode information, allowing animals to perform complex behaviors such as learning and memory. In addition, alterations in synaptic plasticity are associated with human diseases, including Alzheimer disease, epilepsy, chronic pain, drug addiction, and schizophrenia. Long-term potentiation (LTP) and depression (LTD) in the hippocampal region of the brain are two forms of synaptic plasticity that increase or decrease, respectively, the strength of synaptic transmission by postsynaptic AMPA-type glutamate receptors. Both LTP and LTD are induced by activation of NMDA-type glutamate receptors but differ in the level and duration of Ca 2+ influx through the NMDA receptor and the subsequent engagement of downstream signaling by protein kinases, including PKA, PKC, and CaMKII, and phosphatases, including PP1 and calcineurin-PP2B (CaN). This review addresses the important emerging roles of the A-kinase anchoring protein family of scaffold proteins in regulating localization of PKA and other kinases and phosphatases to postsynaptic multiprotein complexes that control NMDA and AMPA receptor function during LTP and LTD.
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“AKAP5 anchors both PKA and CaN to GluA1 allowing for the efficient coordination of these signaling pathways during LTD (Sanderson and Dell'Acqua, 2011).”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Sanderson and Dell'Acqua, 2011
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Cites
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Mechanisms of CaMKII action in long-term potentiation
Lisman, J., Yasuda, R., & Raghavachari, S. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3192 · Cited by 1,134
The AMPA Receptor Code of Synaptic Plasticity
Diering, G. H., & Huganir, R. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.018 · Cited by 844
Riazi, K., Galic, M. A., Kentner, A. C., Reid, A. Y., Sharkey, K. A., & Pittman, Q. J. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.4485-14.2015 · Cited by 228
Creating Order from Chaos: Cellular Regulation by Kinase Anchoring
Scott, J. D., DESSAUER, C. W., & Taskén, K. (2012) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140204 · Cited by 216
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Metadata
- Authors
- Sanderson, J. L., & Dell'Acqua, M. L.
- Affiliations
- University of Colorado Anschutz (US)
- Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA, Program in Neuroscience, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA,
- Venue
- The Neuroscientist
- Publisher
- SAGE Publications
- Published
- 2011-04-15
- Volume
- 17
- Issue
- 3
- Pages
- 321-336
- ISSN
- 1073-8584 (ISSN-L)
- 1089-4098
- PMC
- PMC3126619
- OpenAlex
- W2126128061
- Cited by
- 185
- References
- 89
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 12 · 2023: 7 · 2022: 9 · 2021: 8 · 2020: 4 · 2019: 9 · 2018: 8 · 2017: 12 · 2016: 16 · 2015: 24 · 2014: 23 · 2013: 20 · 2012: 17
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Neuroscientist (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (T32AA007464)
- National Institute of Mental Health (R01MH080291)
- National Institute of Neurological Disorders and Stroke (R01NS040701)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- A-kinase anchoring proteins, synaptic plasticity, long-term potentiation, long-term depression, NMDA receptor, AMPA receptors, calcium/calmodulin-dependent protein kinase II, protein kinase A, protein kinase C, calcineurin, scaffold proteins, hippocampus, glutamatergic synapses
- MeSH terms
- Animals, Brain, Humans, Synaptic Transmission, Neuronal Plasticity, Signal Transduction, A Kinase Anchor Proteins
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