Working Memory and Response Inhibition as One Integral Phenotype of Adult ADHD? A Behavioral and Imaging Correlational Investigation
Open accessAbstract
Objective: It is an open question whether working memory (WM) and response inhibition (RI) constitute one integral phenotype in attention deficit hyperactivity disorder (ADHD). Method: The authors investigated 45 adult ADHD patients and 41 controls comparable for age, gender, intelligence, and education during a letter n-back and a stop-signal task, and measured prefrontal oxygenation by means of functional near-infrared spectroscopy. Results: The authors replicated behavioral and cortical activation deficits in patients compared with controls for both tasks and also for performance in both control conditions. In the patient group, 2-back performance was correlated with stop-signal reaction time. This correlation did not seem to be specific for WM and RI as 1-back performance was correlated with go reaction time. No significant correlations of prefrontal oxygenation between WM and RI were found. Conclusion: The authors’ findings do not support the hypothesis of WM and RI representing one integral phenotype of ADHD mediated by the prefrontal cortex.
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The EFs that children with ADHD show deficits on are largely related to different brain regions.
“and that these EFs are largely related to different brain regions [25], [26], [27]”
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References 74 · Cited by 42
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- Authors
- Schecklmann, M., Ehlis, A.-C., Plichta, M. M., Dresler, T., Heine, M., Boreatti-Hümmer, A., Romanos, M., Jacob, C., Pauli, P., & Fallgatter, A. J.
- Affiliations
- University of Würzburg (DE)
- Heidelberg University (DE)
- University of Würzburg, Germany
- ORCID
- Venue
- Journal of Attention Disorders
- Publisher
- SAGE Publications
- Published
- 2012-02-08
- Volume
- 17
- Issue
- 6
- Pages
- 470-482
- ISSN
- 1087-0547 (ISSN-L)
- 1557-1246
- OpenAlex
- W2037295230
- Cited by
- 42
- References
- 74
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 7 · 2014: 7 · 2013: 7 · 2012: 1
- FWCI
- 5.01
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Journal of Attention Disorders (publishedVersion)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion)
- University of Regensburg Publication Server (University of Regensburg)
- Funders
- Deutsche Forschungsgemeinschaft (KFO 125-1, KFO125)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Keywords
- adult ADHD, working memory, response inhibition, prefrontal cortex, functional near-infrared spectroscopy, stop-signal task, reaction time, cognitive phenotypes
- MeSH terms
- Adult, Attention Deficit Disorder with Hyperactivity, Female, Humans, Impulsive Behavior, Inhibition, Psychological, Male, Memory, Short-Term, Neuropsychological Tests, Oxygen, Phenotype, Psychiatric Status Rating Scales, Prefrontal Cortex, Spectroscopy, Near-Infrared, Young Adult, Functional Neuroimaging
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