A Toxicological Assessment of Creatyl- l -Leucine
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A battery of toxicological studies was conducted to investigate the genotoxicity and repeated-dose oral toxicity of creatyl-l-leucine, a synthetic compound, in rats in accordance with internationally accepted guidelines. There was no evidence of mutagenicity in a bacterial reverse mutation test and in an in vitro mammalian chromosomal aberration test. There was no genotoxic activity observed in an in vivo mammalian micronucleus test at concentrations up to the limit dose of 2,000 mg/kg bw/d. Creatyl-l-leucine did not cause mortality or toxic effects in Hsd.Han Wistar rats in a 90-day repeated-dose oral (gavage) toxicity study at doses of 1,250, 2,500, and 5,000 mg/kg bw/d. The no observed adverse effect level from the 90-day study was determined to be 5,000 mg/kg bw/d, the highest dose tested, for both male and female rats.
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A toxicology study found that CLL did not cause mortality, toxic effects, or adverse effects in rats administered CLL for 90 days by oral gavage at doses of 1250, 2500, and 5000 mg/kg/day.
“This study found that CLL did not cause mortality, toxic effects, or adverse effects in rats administered CLL for 90-days by oral gavage at doses of 1250, 2500, and 5000 mg/kg/day.”
From Bioavailability, Efficacy, Safety, and Regulatory Status of Creatine and Related Compounds: A Critical Review (2022) · cites this paper as [220]
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Kreider, R. B., Jäger, R., & Purpura, M. (2022) · Nutrients · doi:10.3390/nu14051035 · Cited by 103 · see citing works
- Authors
- Reddeman, R. A., Glávits, R., Endres, J. R., Murbach, T. S., Hirka, G., Vértesi, A., Béres, E., & Szakonyiné, I. P.
- Affiliations
- AIBMR Life Sciences, Inc, Seattle, WA, USA
- Toxi-Coop Zrt., Budapest, Hungary
- Corresponding author
- Reddeman, Robin A.
- Venue
- International Journal of Toxicology
- Publisher
- SAGE Publications
- Published
- 2018-01-22
- Volume
- 37
- Issue
- 2
- Pages
- 171-187
- ISSN
- 1091-5818 (ISSN-L)
- 1092-874X
- OpenAlex
- W2786583459
- Cited by
- 6
- References
- 6
- Citations by year
- 2022: 2 · 2019: 4
- FWCI
- 0.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vital Pharmaceuticals Inc. Weston, FL
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural safety and regulations
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Keywords
- genotoxicity, repeated dose oral toxicity, no-observed-adverse-effect level, mutagenicity, bacterial reverse mutation test, chromosomal aberration test, micronucleus test, 90-day toxicity study
- MeSH terms
- Animals, Cell Line, Cricetulus, Erythrocytes, Escherichia coli, Female, Leucine, Male, Salmonella typhimurium, Rats, Wistar, Toxicity Tests, No-Observed-Adverse-Effect Level, Mice
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