Breaking down the gut microbiome composition in multiple sclerosis
Open accessAbstract
BACKGROUND: The gut microbiome, which consists of a highly diverse ecologic community of micro-organisms, has increasingly been studied regarding its role in multiple sclerosis (MS) immunopathogenesis. This review critically examines the literature investigating the gut microbiome in MS. METHODS: A comprehensive search was performed of PubMed databases and ECTRIMS meeting abstracts for literature relating to the gut microbiome in MS. Controlled studies examining the gut microbiome in patients with MS were included for review. RESULTS: Identified studies were predominantly case-control in their design and consistently found differences in the gut microbiome of MS patients compared to controls. We examine plausible mechanistic links between these differences and MS immunopathogenesis, and discuss the therapeutic implications of these findings. CONCLUSIONS: Review of the available literature reveals potential immunopathogenic links between the gut microbiome and MS, identifies avenues for therapeutic advancement, and emphasizes the need for further systematic study in this emerging field.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Psychiatric and neurodevelopmental illnesses, including major depressive disorder, autism spectrum disorder, and multiple sclerosis, are consistently associated with a state of dysbiosis.
“Psychiatric and neurodevelopmental illnesses, including major depressive disorder [49,50], autism spectrum disorder [51], and multiple sclerosis [26], are consistently associated with a state of dysbiosis.”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 45 · Cited by 51
Research works printed but not linked: 5
- Castillo Alvarez F, Perez Matute P, Colina Lizuain S, et al. Intestinal microbiota in multiple sclerosis: Influence of treatment with interferon β-1b. In: Proceedings of the ECTRIMS 2016, London, http://onlinelibrary.ectrims- congress.eu/ectrims/2016/32nd/146290/federico. castillo.lvarez.intestinal.microbiota.in.multiple.sclerosis. influence.html?f=m3
- Cekanaviciute E, Debelius JW, Singh S, et al. Gut dysbiosis is a feature of MS and it is characterized by bacteria able to regulate lymphocyte differentiation in vitro. In: Proceedings of the ECTRIMS 2016, London, http://onlinelibrary.ectrims-congress.eu/ ectrims/2016/32nd/147026/sergio.e.baranzini.gut. dysbiosis.is.a.feature.of.ms.and.it.is.characterized. by.html?f=m3
- Dusha A, Jorg S, Berg J, et al. The effect of the short chain fatty acid propionate on immune regulation in MS: A proof-of-concept study. In: Proceedings of the ECTRIMS 2016, London, http://onlinelibrary. ectrims-congress.eu/ectrims/2016/32nd/145844/ alexander.duscha.the.effect.of.the.short.chain.fatty. acid.propionate.on.immune.html?f=m3
- Casaccia P, Zhu Y, Cekanaviciute E, et al. Effect of oral versus injectable disease-modifying therapies on the epigenome-wide DNA methylation and gut microbiota in multiple sclerosis patients. In: Proceedings of the ECTRIMS 2016, London, http://onlinelibrary.ectrims-congress.eu/ ectrims/2016/32nd/145837/patrizia.casaccia.effect. of.oral.versus.injectable.disease-modifying.therapies. html?f=m3
- Baranzini SE. The international MS microbiome study (iMSMS): Investigating the role of gut microbiota in multiple sclerosis through open collaboration. In: Proceedings of the ECTRIMS 2016, London, http://onlinelibrary.ectrims-congress. eu/ectrims/2016/32nd/146272/sergio.e.baranzini. the.international.ms.microbiome.study.28imsms29. investigating.html?f=m3
- Authors
- Budhram, A., Parvathy, S., Kremenchutzky, M., & Silverman, M.
- Affiliations
- University Hospital (CA)
- St Joseph's Health Care (CA)
- Corresponding author
- Budhram, Adrian
- Venue
- Multiple Sclerosis Journal
- Publisher
- SAGE Publications
- Published
- 2016-12-12
- Volume
- 23
- Issue
- 5
- Pages
- 628-636
- ISSN
- 1352-4585 (ISSN-L)
- 1477-0970
- OpenAlex
- W2565583047
- Cited by
- 51
- References
- 45
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 3 · 2023: 8 · 2022: 8 · 2021: 4 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 6
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Multiple Sclerosis Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- gut microbiota, multiple sclerosis, immunopathogenesis, dysbiosis, microbiota composition, therapeutic target, neuroinflammation
- MeSH terms
- Gastrointestinal Microbiome, Animals, Humans, Infections, Multiple Sclerosis, Bacteroidetes, Gastrointestinal Tract, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
