The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
New insights into the burden and costs of multiple sclerosis in Europe
Open accessAbstract
Background: The current focus in multiple sclerosis (MS) is on early diagnosis and drug intervention, with a view to modifying disease progression. Consequently, healthcare costs have shifted from inpatient care and rehabilitation to outpatient care. Objectives: This European burden of illness study provides data that can be combined with other evidence to assess whether management approaches provide value to society. Methods: A cross-sectional study was conducted in 16 countries. Patients reported on their disease, health-related quality of life (HRQoL) and resource consumption. Descriptive analyses were performed by disease severity. Costs are reported from a societal perspective in 2015€ PPP (adjusted for purchasing power parity). Results: The 16,808 participants had a mean age of 51.5 years, and 52% had relapsing–remitting multiple sclerosis (RRMS). Work capacity declined from 82% to 8%, and utility declined from normal population values to less than zero with advancing disease. Mean costs were 22,800€ PPP in mild, 37,100€ PPP in moderate and 57,500€ PPP in severe disease; healthcare accounted for 68%, 47% and 26%, respectively. Fatigue and cognitive difficulties were reported by 95% and 71% of participants, respectively; both had a significant independent effect on utility. Conclusion: Costs and utility were highly correlated with disease severity, but resource consumption was heavily influenced by healthcare systems organisation and availability of services.
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Cites
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Self-citationBrain health: time matters in multiple sclerosis
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Cited by
Filippi, M., Bar-Or, A., Piehl, F., Preziosa, P., Solari, A., Vukusic, S., & Rocca, M. A. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0041-4 · Cited by 1,562
Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy
Muzio, L., Viotti, A., & Martino, G. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.742065 · Cited by 581
Solleiro-Villavicencio, H., & Rivas-Arancibia, S. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00114 · Cited by 463
Wolinsky, J. S., Arnold, D. L., Brochet, B., Hartung, H.-P., Montalban, X., Naismith, R. T., Manfrini, M., Overell, J., Koendgen, H., Sauter, A., et al. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30342-2 · Cited by 150
Current and emerging disease‐modulatory therapies and treatment targets for multiple sclerosis
Piehl, F. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13215 · Cited by 125
Metadata
- Authors
- Kobelt, G., Thompson, A., Berg, J., Gannedahl, M., Eriksson, J., the MSCOI Study Group, & Platform, T. E. M. S.
- Venue
- Multiple Sclerosis Journal
- Publisher
- SAGE Publications
- Published
- 2017-02-01
- Volume
- 23
- Issue
- 8
- Pages
- 1123-1136
- ISSN
- 1352-4585 (ISSN-L)
- 1477-0970
- OpenAlex
- W2591088516
- Cited by
- 733
- References
- 17
- FWCI
- 39.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
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