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B–lymphoblastoid cell lines from multiple sclerosis patients and a healthy control producing a putative new human retrovirus and Epstein–Barr virus
Open accessAbstract
On several occasions we have observed retrovirus-like particles (RVLPs) by transmission electron microscopy (EM) of cultured T cells from a patient with MS. Later we established spontaneously formed B-lymphoblastoid cell lines (LCLs) from a patient with an MS-like disease and from another patient with MS who had a reactivated Epstein-Barr virus (EBV) infection. Both LCLs were found by EM to produce RVLP and EBV particles. Reverse transcriptase (RT) assays were positive in purified viral material from both LCLs. To substantiate these findings we initiated an intensified culturing procedure and were able to establish LCLs from 5 out of 21 consecutive MS patients and 1 out of 13 consecutive healthy controls. All LCLs were found to produce both RVLP and EBV particles by EM. Whether the putative new retrovirus(es) and EBV have any causal relationship to MS is still not known, but the findings support this possibility.
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Retrovirus-like particles can be induced in transformed B cells from healthy donors.
“and retrovirus-like particles can also be induced in transformed B cells from healthy donors 79.”
From Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis (2013) · cites this paper as [79]
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Human RNA “Rumor” Viruses: the Search for Novel Human Retroviruses in Chronic Disease
Voisset, C., Weiss, R. A., & Griffiths, D. J. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00033-07 · Cited by 157
Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis
Young, G. R., Stoye, J. P., & Kassiotis, G. (2013) · BioEssays · doi:10.1002/bies.201300049 · Cited by 78
Metadata
- Authors
- Munch, M., Møller-Larsen, A., Christensen, T., Morling, N., Hansen, H. J., & Haahr, S.
- Affiliations
- Aarhus University (DK)
- University of Copenhagen (DK)
- Aarhus University Hospital (DK)
- Venue
- Multiple Sclerosis Journal
- Publisher
- SAGE Publications
- Published
- 1995-06
- Volume
- 1
- Issue
- 2
- Pages
- 78-81
- ISSN
- 1352-4585 (ISSN-L)
- 1477-0970
- OpenAlex
- W1943390855
- Cited by
- 45
- References
- 1
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 3 · 2017: 1 · 2016: 1 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Multiple Sclerosis Journal (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Aarhus Universitet
- Aarhus Universitetshospital
- Scleroseforeningen
- Multiple Sclerosis Society
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Keywords
- multiple sclerosis, B-lymphoblastoid cell lines, retrovirus-like particles, Epstein-Barr virus, viral etiology of multiple sclerosis, EBV reactivation, T cell culture
- MeSH terms
- Adult, B-Lymphocytes, Cell Line, Transformed, DNA-Binding Proteins, Herpesvirus 4, Human, Female, Humans, Male, Multiple Sclerosis, Retroviridae, Viral Proteins, Virus Replication, Trans-Activators, Virus Latency
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