The association between epilepsy and autism symptoms and maladaptive behaviors in children with autism spectrum disorder
Open accessAbstract
Epilepsy is common in children with autism spectrum disorder (ASD) but little is known about how seizures impact the autism phenotype. The association between epilepsy and autism symptoms and associated maladaptive behaviors was examined in 2,645 children with ASD, of whom 139 had epilepsy, from the Simons Simplex Collection. Children with ASD and epilepsy had significantly more autism symptoms and maladaptive behaviors than children without epilepsy. However, after adjusting for IQ, only hyperactivity symptoms remained significantly increased (13% higher) in the epilepsy group. Among children with ASD without co-occurring intellectual disability, children with epilepsy had significantly more irritability (20% higher) and hyperactivity (24% higher) symptoms. This is the largest study to date comparing the autism phenotype in children with ASD with and without epilepsy. Children with ASD and epilepsy showed greater impairment than children without epilepsy, which was mostly explained by the lower IQ of the epilepsy group. These findings have important clinical implications for patients with ASD.
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Comorbid epilepsy often occurs in conjunction with ID and was associated with worse behavioral and social outcomes, increased motor difficulties, and more challenging behavior compared with ASD alone.
“Comorbid epilepsy often occurs in conjunction with ID and was associated with worse behavioral and social outcomes, increased motor difficulties and more challenging behavior compared with ASD alone (59).”
From Prevalence of Autism Spectrum Disorder and Co-morbidities in Children and Adolescents: A Systematic Literature Review (2021) · cites this paper as [59]
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References 59 · Cited by 82
Research works printed but not linked: 1
- Volkmar FR Nelson DS 1990 Seizure disorders in autism J Am Acad Child Adolesc Psychiatry 29 1 127 129 2295565
- Authors
- Viscidi, E. W., Johnson, A. L., Spence, S. J., Buka, S. L., Morrow, E. M., & Triche, E. W.
- Affiliations
- Brown University (US)
- Harvard University (US)
- Venue
- Autism
- Publisher
- SAGE Publications
- Published
- 2013-10-28
- Volume
- 18
- Issue
- 8
- Pages
- 996-1006
- ISSN
- 1362-3613 (ISSN-L)
- 1461-7005
- PMC
- PMC4002664
- OpenAlex
- W2157539143
- Cited by
- 82
- References
- 59
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 9 · 2023: 4 · 2022: 5 · 2021: 15 · 2020: 9 · 2019: 9 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 3 · 2014: 2
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Autism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Burroughs Wellcome Fund
- Brown University
- National Institutes of Health
- National Institute of General Medical Sciences (P20GM103645)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- autism spectrum disorder, epilepsy, seizures, autism phenotype, maladaptive behavior, hyperactivity, irritability, intellectual disability, IQ, children
- MeSH terms
- Adolescent, Child, Child Behavior Disorders, Child Development Disorders, Pervasive, Child, Preschool, Epilepsy, Female, Humans, Male, Intellectual Disability, United States, Comorbidity
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