The added value of 18-fluorodeoxyglucose-positron emission tomography in the diagnosis of the behavioral variant of frontotemporal dementia
Open accessAbstract
Characteristic frontotemporal abnormalities on structural or functional neuroimaging are mandatory for a diagnosis of probable behavioral variant of frontotemporal dementia (bvFTD) according to the new criteria. 18-Fluorodeoxyglucose-positron emission tomography (18F-FDG-PET) imaging is commonly reserved for patients with suspected bvFTD without characteristic structural neuroimaging results. We studied the diagnostic value of 18F-FDG-PET in these patients. Methods: The 18F-FDG-PET was performed in 52 patients with suspected bvFTD but lacking characteristic structural neuroimaging results. The clinical diagnosis of bvFTD in the presence of functional decline (bvFTD/fd+) after a follow-up period of 2 years was used as a golden standard. Results: The sensitivity of 18F-FDG-PET for bvFTD/fd+ was 47% at a specificity of 92%. The differential diagnosis comprised alternative neurodegenerative and psychiatric disorders and a benign phenocopy of bvFTD. Conclusions: The 18F-FDG-PET is able to identify nearly half of the patients with bvFTD who remain undetected by magnetic resonance imaging. In our selected group, high specificity enables exclusion of psychiatric and other neurodegenerative disorders.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
FDG-PET in 52 patients with suspected bvFTD but no characteristic atrophy on structural imaging was 47% sensitive and 92% specific.
“FDG-PET performed in 52 patients with suspected bvFTD but not having characteristic atrophy patterns on structural imaging was 47% sensitive and 92% specific, showing that is able to identify nearly half of the patients with bvFTD undetected by MRI with high specificity, enabling exclusion of psychiatric and other neurodegenerative disorders [132].”
From The use of neuroimaging techniques in the early and differential diagnosis of dementia (2023) · cites this paper as [132]
PET provides a higher imaging sensitivity by identifying half of the bvFTD cases that remain undetected by MRI techniques.
“PET provides a higher imaging sensitivity by identifying half of the bvFTD cases that remain undetected by MRI techniques (Kerklaan et al. , 2014).”
From Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders (2020) · cites this paper as Kerklaan et al. , 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589 · see citing works
Koenigs, M., & Grafman, J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.004 · Cited by 956 · cited 1× · see citing works
“4) 61 (7) 64 (6) Median follow-up duration, months (range) 33 (24-58) 40 (24-56) 44 (26-58) Median disease duration, years (range) 3 (0.”
Kipps, C. M., Davies, R. R., Mitchell, J., Kril, J. J., Halliday, G. M., & Hodges, J. R. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000100973 · Cited by 172 · see citing works
Flagged first, then by citations
Research works printed but not linked: 29
- Neary D, Snowden JS, Gustafson L, et al. Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurol- ogy. 1998;51(6):1546-1554.
- Knopman DS, Boeve BF, Parisi JE, et al. Antemortem diagnosis of frontotemporal lobar degeneration. Ann Neurol. 2005;57(4): 480-488.
- Mendez MF. The accuracy of clinical criteria for the diagnosis of frontotemporal dementia. Int J Psychiatry Med. 2004;34(2): 125-130.
- Piguet O, Hornberger M, Shelley BP, Kipps CM, Hodges JR. Sensitivity of current criteria for the diagnosis of behavioral variant frontotemporal dementia. Neurology. 2009;72(8): 732-737.
- Pijnenburg YA, Mulder JL, van Swieten JC, et al. Diagnostic accuracy of consensus diagnostic criteria for frontotemporal dementia in a memory clinic population. Dement Geriatr Cogn Disord. 2008;25(2):157-164.
- Rascovsky K, Hodges JR, Kipps CM, et al. Diagnostic criteria for the behavioral variant of frontotemporal dementia (bvFTD): current limitations and future directions. Alzheimer Dis Assoc Disord. 2007;21(4):S14-S18.
- Gregory CA, Hodges JR. Clinical features of frontal lobe demen- tia in comparison to Alzheimer's disease. J Neural Transm Suppl. 1996;47:103-123.
- Panegyres PK, Graves A, Frencham KA. The clinical differentia- tion of fronto-temporal dementia from psychiatric disease. Neuropsychiatr Dis Treat. 2007;3(5):637-645.
- Mendez MF, Shapira JS, McMurtray A, Licht E, Miller BL. Accuracy of the clinical evaluation for frontotemporal dementia. Arch Neurol. 2007;64(6):830-835.
- Woolley JD, Khan BK, Murthy NK, Miller BL, Rankin KP. The diagnostic challenge of psychiatric symptoms in neurodegenera- tive disease: rates of and risk factors for prior psychiatric diagno- sis in patients with early neurodegenerative disease. J Clin Psychiatry. 2011;72(2):126-133.
- Varma AR, Snowden JS, Lloyd JJ, Talbot PR, Mann DM, Neary D. Evaluation of the NINCDS-ADRDA criteria in the differentiation of Alzheimer's disease and frontotemporal dementia. J Neurol Neurosurg Psychiatry. 1999;66(2):184-188.
- Mendez MF, Selwood A, Mastri AR, Frey WH. Pick's disease versus Alzheimer's disease: a comparison of clinical characteris- tics. Neurology. 1993;43(2):289-292.
- Rosen HJ, Hartikainen KM, Jagust W, et al. Utility of clinical cri- teria in differentiating frontotemporal lobar degeneration (FTLD) from AD. Neurology. 2002;58(11):1608-1615.
- Josephs KA, Whitwell JL, Jack CR, Parisi JE, Dickson DW. Frontotemporal lobar degeneration without lobar atrophy. Arch Neurol. 2006;63(11):1632-1638.
- Koedam EL, Van der Flier WM, Barkhof F, Koene T, Scheltens P, Pijnenburg YA. Clinical characteristics of patients with fronto- temporal dementia with and without lobar atrophy on MRI. Alzheimer Dis Assoc Disord. 2010;24(3):242-247.
- Videbech P. PET measurements of brain glucose metabolism and blood flow in major depressive disorder: a critical review. Acta Psychiatr Scand. 2000;101(1):11-20.
- Erkwoh R, Sabri O, Steinmeyer EM, Bu ¨ll U, Sab H. Psychopatho- logical and SPECT findings in never-treated schizophrenia. Acta Psychiatr Scand. 1997;96(1):51-57.
- Sachdev P, Brodaty H, Rose N, Haindl W. Regional cerebral blood flow in late-onset schizophrenia: a SPECT study using 99mTc-HMPAO. Schizophren Res. 1997;27(2-3):105-117.
- McKeith IG, Galasko D, Kosaka K, et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology. 1996;47(5):1113-1124.
- McKeith IG, Dickson DW, Lowe J, et al. Diagnosis and manage- ment of dementia with Lewy bodies. third report of the DLB consortium. Neurology. 2005;65(12):1863-1872.
- McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer's disease. Neurology. 1984;34(7):939-944.
- Roman GC, Tatemichi TK, Erkinjuntti T, et al. Vascular demen- tia: diagnostic criteria for research studies. Report of the NINDS- AIREN international workshop. Neurology. 1993;43(2):250-260.
- Folstein MF, Folstein SE, McHugh PR. ''Mini-mental state.'' A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1995;12(3):189-198.
- Dubois B, Slachevsky A, Litvan I, Pillon B. The FAB: a frontal assessment battery at bedside. Neurology. 2000;55(11): 1621-1626.
- Brix G, Zaers J, Adam LE, et al. Performance evaluation of a whole-body PET scanner using the NEMA protocol. national electrical manufacturers association. J Nucl Med. 1997;38(10): 1614-1623.
- Herholz K, Salmon E, Perani D, et al. Discrimination between Alzheimer dementia and controls by automated analysis of multi- center FDG PET. Neuroimage. 2002;17(1):302-316.
- Khan BK, Yokoyama JS, Takada LT, et al. Atypical, slowly pro- gressive behavioural variant frontotemporal dementia associated with C9ORF72 hexanucleotide expansion. J Neurol Neurosurg Psychiatry. 2012;83(4):358-364.
- Kipps CM, Hodges JR, Hornberger M. Nonprogressive behavioural frontotemporal dementia: recent developments and clinical implications of the 'bvFTD phenocopy syndrome'. Curr Opin Neurol. 2010;23(6):628-632.
- Diehl-Schmid J, Grimmer T, Drzezga A, et al. Decline of cerebral glucose metabolism in frontotemporal dementia: a longitudinal 18F-FDG-PET-study. Neurobiol Aging. 2007;28(1):42-50.
Cited by
Sorted by citations
Ducharme, S., Dols, A., Laforce, R., Devenney, E., Kumfor, F., van den Stock, J., Dallaire-Théroux, C., Seelaar, H., Gossink, F., Vijverberg, E., et al. (2020) · Brain · doi:10.1093/brain/awaa018 · Cited by 320 · see citing works
Self-citationThe use of neuroimaging techniques in the early and differential diagnosis of dementia
Chouliaras, L., & O’Brien, J. T. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02215-8 · Cited by 186 · see citing works
“…but not having characteristic atrophy patterns on structural imaging was 47% sensitive and 92% speci fi c, showing that is able to identify nearly half of the patients with bvFTD undetected by MRI with high speci fi city, enabling exclusion of psychiatric and other neurodegenerative disorders [132].”
BackgroundVijverberg, E. G. B., Wattjes, M. P., Dols, A., Krudop, W. A., Möller, C., Peters, A., Kerssens, C. J., Gossink, F., Prins, N. D., Stek, M. L., et al. (2016) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160285 · Cited by 92 · see citing works
Self-citationPhenocopy syndrome of behavioral variant frontotemporal dementia: a systematic review
Valente, E. S., Caramelli, P., Gambogi, L. B., Mariano, L. I., Guimarães, H. C., Teixeira, A. L., & de Souza, L. C. (2019) · Alzheimer's Research & Therapy · doi:10.1186/s13195-019-0483-2 · Cited by 54 · see citing works
FTD spectrum: Neuroimaging across the FTD spectrum
Whitwell, J. L. (2019) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2019.05.009 · Cited by 53 · see citing works
Gossye, H., Van Broeckhoven, C., & Engelborghs, S. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00757 · Cited by 34 · see citing works
Zhutovsky, P., Vijverberg, E. G. B., Bruin, W. B., Thomas, R. M., Wattjes, M. P., Pijnenburg, Y. A. L., van Wingen, G. A., & Dols, A. (2019) · Journal of Alzheimer's Disease · doi:10.3233/jad-181004 · Cited by 20 · see citing works
Self-citation
- Authors
- Kerklaan, B. J., van Berckel, B. N. M., Herholz, K., Dols, A., van der Flier, W. M., Scheltens, P., & Pijnenburg, Y. A. L.
- Affiliations
- Sint Lucas Andreas Hospital (NL)
- Department of Nuclear Medicine, VU Medical Center, Amsterdam, The Netherlands
- University of Manchester (GB)
- GGZ inGeest (NL)
- Alzheimer Center VU Medical Center, Amsterdam, The Netherlands
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Kerklaan, B. J.
- Venue
- American Journal of Alzheimer's Disease & Other Dementias®
- Publisher
- SAGE Publications
- Published
- 2014-02-26
- Volume
- 29
- Issue
- 7
- Pages
- 607-613
- ISSN
- 0888-4897 (ISSN-L)
- 1533-3175
- 1938-2731
- PMC
- PMC10852737
- OpenAlex
- W2168210007
- Cited by
- 46
- References
- 3
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 3 · 2023: 1 · 2021: 5 · 2020: 2 · 2019: 7 · 2018: 6 · 2016: 7 · 2015: 4 · 2014: 2
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Alzheimer s Disease & Other Dementias® (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- behavioral variant frontotemporal dementia, 18F-FDG PET, diagnostic accuracy, sensitivity and specificity, differential diagnosis, mental illness, neurodegenerative diseases, phenocopy, functional decline, magnetic resonance imaging
- MeSH terms
- Cerebrospinal Fluid, Diagnosis, Differential, Electroencephalography, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Retrospective Studies, Sensitivity and Specificity, Radiopharmaceuticals, Fluorodeoxyglucose F18, Positron-Emission Tomography, Frontotemporal Dementia, Neuroimaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
