Lack of Genetic Association Between TREM2 and Alzheimer’s Disease in East Asian Population: A Systematic Review and Meta-Analysis
Open accessAbstract
Purpose Large-scale genome-wide association studies have identified TREM2 variants to be significantly associated with Alzheimer's disease (AD) in caucasian population. The goal of this systematic study and meta-analysis was to assess the association between Triggering receptor expressed on myeloid cells 2 (TREM2) variants and AD in East Asian population. Methods In this study, literatures were searched in PubMed, MEDLINE, EMBASE, and the Cochrane library to screen citations from January 1990 to June 2014. Data analysis was done by using the Stata 12 software. Results Twelve studies were considered for analysis. A total of 13 535 patients with AD and 22 976 healthy controls were studied. The results showed that rs75932628 variant was significantly associated with AD in caucasian population (P Conclusion In our study, we found that TREM2 variant is likely not associated with AD in East Asian population.
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TREM2 variants associate with an increased risk of AD.
“Importantly, TREM2 variants associate with an increased risk of AD [15, 25, 38–40].”
From Protective PLCG2 variants associate with a delayed onset of Alzheimer’s disease among heterozygous APOE ε4 carriers (2026) · cites this paper as [38]
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References 17 · Cited by 25
- Authors
- Huang, M., Wang, D., Xu, Z., Xu, Y., Xu, X., Ma, Y., & Xia, Z.
- Affiliations
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang Chinese Medical University (CN)
- Laboratory Animal Research Center, Zhejiang Chinese Medical University, Hangzhou, China
- Corresponding author
- Ma, Yuefeng
- Venue
- American Journal of Alzheimer's Disease & Other Dementias®
- Publisher
- SAGE Publications
- Published
- 2015-04-07
- Volume
- 30
- Issue
- 6
- Pages
- 541-546
- ISSN
- 0888-4897 (ISSN-L)
- 1533-3175
- 1938-2731
- PMC
- PMC10852690
- OpenAlex
- W2157912014
- Cited by
- 25
- References
- 17
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 2
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Alzheimer s Disease & Other Dementias® (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- TREM2, Alzheimer's disease, genetic association, East Asian populations, genetic susceptibility, ethnic differences in genetic risk
- MeSH terms
- Alzheimer Disease, Asia, Eastern, Humans, Membrane Glycoproteins, Receptors, Immunologic, White People, Asian People
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