Sonodynamic and Photodynamic Therapy in Advanced Breast Carcinoma: A Report of 3 Cases
Open accessAbstract
Photodynamic therapy (PDT) is an established therapeutic method, first approved by the FDA for certain kinds of cancer in 1998. There are also increasing data to show that a related procedure, sonodynamic therapy (SDT), is a promising new modality for cancer treatment. Here, the authors report clinical results in 3 advanced refractory breast cancer patients who were treated using a combination of sonodynamic and photodynamic therapy (SPDT), along with conventional therapies. All 3 patients had pathologically proven metastatic breast carcinoma. These widely disseminated carcinomas had ultimately failed to respond to conventional therapy. A new sensitizing agent, Sonoflora 1™ (SF1) was administered sublingually; then, after a 24-hour delay, patients were treated with a combination of light and ultrasound. All patients had significant partial or complete responses. SPDT is a promising new therapeutic combination for the treatment of breast cancer.
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SDT was first introduced for tumor treatment in 1990 and has mainly been clinically tested for brain tumors, whereas its application for breast cancer remains in the preclinical stage.
“First introduced for tumor treatment in 1990, SDT has mainly been clinically tested for brain tumors, whereas its application for breast cancer remains in the preclinical stage [14–20].”
From Nanosensitizer-assisted sonodynamic therapy for breast cancer (2025) · cites this paper as [14]
In three patients with metastatic breast cancer who did not respond to traditional therapy, SPDT treatment with SF1 improved tumors and vital signs to varying degrees.
“Wang et al. first reported SPDT treatment in three patients with metastatic breast cancer who did not respond to traditional therapy in clinical settings [14].”
From Nanosensitizer-assisted sonodynamic therapy for breast cancer (2025) · cites this paper as [14]
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References 12 · Cited by 134
- Authors
- Wang, X., Zhang, W., Xu, Z., Luo, Y., Mitchell, D., & Moss, R. W.
- Affiliations
- South China Normal University (CN)
- Liu Hua Qiao Hospital, Guangzhou 510010, People's Republic of China
- Corresponding author
- Wang, Xiaohuai
- Venue
- Integrative Cancer Therapies
- Publisher
- SAGE Publications
- Published
- 2009-09
- Volume
- 8
- Issue
- 3
- Pages
- 283-287
- ISSN
- 1534-7354 (ISSN-L)
- 1552-695X
- OpenAlex
- W2164977248
- Cited by
- 134
- References
- 12
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 13 · 2023: 15 · 2022: 16 · 2021: 17 · 2020: 13 · 2019: 3 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 7 · 2014: 6 · 2013: 3 · 2012: 3
- FWCI
- 2.53
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Integrative Cancer Therapies (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Keywords
- sonodynamic therapy, photodynamic therapy, advanced breast cancer, metastatic breast cancer, refractory cancer, photosensitizers, combination therapy, sublingual administration, treatment response
- MeSH terms
- Administration, Sublingual, Adult, Complementary Therapies, Breast Neoplasms, Carcinoma, Chlorophyll, Combined Modality Therapy, Female, Humans, Middle Aged, Neoplasm Metastasis, Photochemotherapy, Ultrasonic Therapy, Treatment Outcome, Photosensitizing Agents, Fatal Outcome, Positron-Emission Tomography
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