CoChat
Sign Up
Cited by 83

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Asbestos-Induced Pulmonary Toxicity: Role of DNA Damage and Apoptosis

Upadhyay, Daya, Kamp, David W.·2003·Experimental Biology and Medicine
DOI 10.1177/153537020322800602
Open this paper in CoChat — free account

Abstract

Asbestos causes asbestosis and various malignancies by mechanisms that are not clearly defined. Here, we review the accumulating evidence showing that asbestos is directly genotoxic by inducing DNA strand breaks (DNA-SB) and apoptosis in relevant lung target cells. Although the exact mechanisms by which asbestos causes DNA damage and apoptosis are not firmly established, some of the implicated mechanisms include the generation of iron-derived reactive oxygen species (ROS) as well as reactive nitrogen species (RNS), alteration in the mitochondrial function, and activation of the death receptor pathway. We focus on the accumulating evidence implicating ROS. DNA repair mechanisms have a key role in limiting the extent of DNA damage. Recent studies show that asbestos activates DNA repair enzymes such as apurinic/apyrimidinic endonuclease (APE) and poly (ADP-ribose) polymerase (PARP). Asbestos-induced neoplastic transformation may result in the setting where DNA damage overwhelms DNA repair in the face of a persistent proliferative signal. Strategies aimed at limiting asbestos-induced oxidative stress may reduce DNA damage and, as such, prevent malignant transformation.

Overview

Integrity signals

Registry

Crossref · 10.1177/153537020322800602

Cites

8 of 8 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 8 references

Research works printed but not linked: 95

  1. 10.1126/science.2153315 · DOI
  2. Ding M, 2000, J Environ Pathol Toxicol Oncol, 19, 129
  3. 10.1016/0891-5849(92)90117-Y · DOI · Paper page
  4. 10.1289/ehp.97105s51073 · DOI
  5. 10.1002/(SICI)1097-4652(199908)180:2<158::AID-JCP3>3.0.CO;2-R · DOI
  6. 10.1136/oem.57.11.782 · DOI
  7. 10.1093/oxfordjournals.aje.a009616 · DOI
  8. 10.1289/ehp.00108s4665 · DOI
  9. 10.1002/ajim.4700030305 · DOI
  10. Bajgnvatula R, 2001, Asbestos: A Moving Target. Asbestos Losses and Expenses That U.S. Insurers Will Incur Are Much More Than Predicted a Few Years Ago Due to Social, Legal and Economic Changes
  11. 10.1023/A:1008952426060 · DOI
  12. Girion L, 2001, Chicago Tribune, 3, 4
  13. 10.1152/ajplung.1995.268.3.L471 · DOI
  14. 10.1172/JCI113660 · DOI
  15. Libbus BL, 1989, Cancer Res, 49, 5713
  16. 10.1038/bjc.1987.170 · DOI
  17. 10.1093/mutage/15.3.239 · DOI
  18. Wang Q, 2000, J Environ Pathol Toxicol Oncol, 19, 13
  19. 10.1006/abbi.1994.1202 · DOI · Paper page
  20. 10.1016/S0891-5849(98)00158-0 · DOI · Paper page
  21. 10.1016/S0891-5849(00)00211-2 · DOI
  22. 10.1023/A:1009617727938 · DOI
  23. 10.1126/science.275.5303.1132 · DOI
  24. 10.1016/S0092-8674(00)80434-1 · DOI · Paper page
  25. 10.1016/S1097-2765(00)80095-7 · DOI
  26. 10.1016/S0092-8674(00)81590-1 · DOI · Paper page
  27. 10.1016/S0092-8674(00)81589-5 · DOI · Paper page
  28. 10.1152/ajplung.1997.272.6.L1031 · DOI
  29. 10.1165/ajrcmb.19.4.3173 · DOI
  30. 10.1152/ajplung.1997.272.6.L1174 · DOI
  31. 10.1172/JCI119010 · DOI
  32. 10.1152/ajplung.1996.271.5.L813 · DOI
  33. 10.1067/mlc.2001.114826 · DOI · Paper page
  34. 10.1152/ajplung.2000.278.3.L528 · DOI
  35. 10.1177/153537029922200307 · DOI
  36. 10.1165/ajrcmb.19.2.3111 · DOI · Paper page
  37. 10.1006/abbi.1994.1493 · DOI
  38. 10.1093/carcin/16.2.319 · DOI · Paper page
  39. 10.1093/carcin/18.4.825 · DOI
  40. Unfried K, 2002, Cancer Res, 62, 99
  41. 10.1016/0891-5849(96)00014-7 · DOI
  42. 10.1126/science.281.5381.1309 · DOI
  43. 10.1023/A:1015949118495 · DOI
  44. 10.1016/S0921-8777(99)00027-0 · DOI
  45. 10.1289/ehp.98106s51191 · DOI
  46. Driscoll KE, 1998, Environ Health Perspect, 106, 1171
  47. 10.1165/rcmb.4903 · DOI
  48. 10.1177/019262339502300606 · DOI
  49. 10.1152/ajplung.1998.275.1.L165 · DOI
  50. Aikoh T, 1998, Intern J Oncol, 12, 1355
  51. Li XY, 1993, Intern J Exp Pathol, 74, 403
  52. 10.1016/S0002-9440(10)65332-1 · DOI
  53. 10.1165/ajrcmb.12.6.7539275 · DOI
  54. 10.1074/jbc.273.21.13245 · DOI
  55. 10.1089/hum.1998.9.9-1381 · DOI
  56. 10.1152/ajplung.00140.2002 · DOI
  57. 10.1289/ehp.97105s51121 · DOI
  58. Zanella CL, 1996, Cancer Res, 56, 5334
  59. 10.1152/ajplung.1997.273.5.L1029 · DOI
  60. 10.1126/science.270.5240.1326 · DOI
  61. 10.1165/ajrcmb.24.4.4225 · DOI
  62. Luster MI, 1998, Toxicol Lett, 28, 102
  63. Simeonova PP, 1996, Am J Physiol Cell Mol Physiol, 15, 787
  64. Simeonova PP, 1997, J Immunol, 159, 3921, 10.4049/jimmunol.159.8.3921 · DOI
  65. 10.1002/(SICI)1096-9896(199910)189:2<258::AID-PATH410>3.0.CO;2-E · DOI
  66. 10.1016/S0002-9440(10)65001-8 · DOI · Paper page
  67. Angel P, 1991, Biochim Biophys Acta, 1072, 129
  68. 10.1002/jcb.240580203 · DOI
  69. Timblin CR, 1995, Cancer Res, 55, 2723
  70. Ding M, 1999, Cancer Res, 59, 1884
  71. Fung H, 1998, Cancer Res, 58, 189
  72. Faux SP, 1997, Environ Health Perspect, 105, 1127
  73. 10.1038/sj.cdd.4400918 · DOI
  74. 10.1165/ajrcmb.17.6.2854 · DOI
  75. 10.1016/S1097-2765(02)00431-8 · DOI
  76. 10.1038/sj.cdd.4400766 · DOI
  77. 10.1128/MCB.14.3.1815 · DOI
  78. 10.1093/emboj/18.6.1559 · DOI
  79. 10.1002/(SICI)1098-2280(1997)30:2<224::AID-EM15>3.0.CO;2-F · DOI
  80. 10.1002/1520-6866(2000)20:5<273::AID-TCM3>3.0.CO;2-1 · DOI
  81. 10.1093/toxsci/68.2.331 · DOI
  82. 10.1165/ajrcmb.18.2.2937m · DOI
  83. Modestou M, 2001, Cancer Res, 61, 3145
  84. 10.1136/thorax.57.4.353 · DOI
  85. 10.1093/nar/29.14.3116 · DOI
  86. 10.1093/carcin/21.7.1329 · DOI
  87. 10.4049/jimmunol.168.11.5675 · DOI
  88. Fung H, 1998, Cancer Res, 58, 189
  89. 10.1016/S1383-5718(00)00093-0 · DOI
  90. 10.1172/JCI112436 · DOI
  91. 10.1021/bi953010z · DOI
  92. 10.1172/JCI119010 · DOI
  93. 10.2310/6650.2001.34092 · DOI
  94. 10.1016/0092-8674(95)90490-5 · DOI
  95. 10.1101/gad.9.5.509 · DOI

Cited by

Sorted by citations

See all 83

Metadata

Authors
Upadhyay, D., & Kamp, D. W.
Venue
Experimental Biology and Medicine
Publisher
Frontiers Media SA
Published
2003-06
Volume
228
Issue
6
Pages
650-659
ISSN
  • 1535-3702
  • 1535-3699
DOI
10.1177/153537020322800602
Cited by
83
References
8
Language
en
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Asbestos-Induced Pulmonary Toxicity: Role of DNA Damage and Apoptosis. https://app.cochat.ai/papers/10.1177/153537020322800602
The paper
Upadhyay, D., & Kamp, D. W. (2003). Asbestos-Induced Pulmonary Toxicity: Role of DNA Damage and Apoptosis. Experimental Biology and Medicine. https://doi.org/10.1177/153537020322800602