Destruction of parotid glands affects nitrate and nitrite metabolism
Abstract
The role of salivary glands in nitrate and nitrite metabolism is poorly understood. The aim of the present study was to investigate the effect of parotid gland ablation on dynamic metabolism of nitrate and nitrite in miniature pigs. The parotid glands of 5 healthy miniature pigs were bilaterally ablated by methyl violet. Concentrations of nitrate and nitrite of whole saliva, serum, and urine samples were analyzed by high-performance liquid chromatography. Results showed that bilateral ablation of the parotid glands led to a significant decrease of nitrate secretion from blood to saliva (P < 0.05) and thus low nitrite levels. Dysfunction of the parotid glands temporarily increased the systemic level of nitrate in miniature pigs after nitrate loading. This study suggests that the parotid glands play an important role in the balance of nitrate and nitrite levels in both whole saliva and the body.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the setting of salivary gland dysfunction, there is a decrease in salivary nitrate concentration and corollary increase in urinary excretion, thereby reducing total body nitrate content and its enterosalivary circulation.
“In the setting of salivary gland dysfunction, there is a decrease in salivary nitrate concentration and corollary increase in urinary excretion, thereby reducing total body nitrate content and its enterosalivary circulation[84,193,231,293].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [293]
The citation lists haven’t been fetched yet
References 30 · Cited by 42
- Authors
- Xia, D. S., Deng, D. J., & Wang, S. L.
- Affiliations
- Capital Medical University (CN)
- ORCID
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2003-02
- Volume
- 82
- Issue
- 2
- Pages
- 101-105
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W1989784136
- Cited by
- 42
- References
- 30
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 2 · 2016: 3 · 2015: 2 · 2013: 1 · 2012: 4
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dental Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Topics
- Health Sciences › Medicine › Physiology › Salivary Gland Disorders and Functions
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- nitrate metabolism, nitrite metabolism, salivary glands, nitrate loading, minipigs, methyl violet
- MeSH terms
- Animals, Chromatography, High Pressure Liquid, Gentian Violet, Male, Nitrate Reductases, Nitrates, Nitrites, Parotid Gland, Saliva, Swine, Swine, Miniature, Potassium Compounds
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
