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Cited by 388Oral microbiology and periodontitis researchOral and gingival health researchPeriodontal Regeneration and Treatments

The DOI matches its Crossref record; 129 of the 129 references it cites were found in a registry or an index.

The Junctional Epithelium: from Health to Disease

Bosshardt, D.D., Lang, N.P.·2005·Journal of Dental Research
DOI 10.1177/154405910508400102
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Abstract

The junctional epithelium is located at a strategically important interface between the gingival sulcus, populated with bacteria, and the periodontal soft and mineralized connective tissues that need protection from becoming exposed to bacteria and their products. Its unique structural and functional adaptation enables the junctional epithelium to control the constant microbiological challenge. The antimicrobial defense mechanisms of the junctional epithelium, however, do not preclude the development of gingival and periodontal lesions. The conversion of the junctional to pocket epithelium, which is regarded as a hallmark in disease initiation, has been the focus of intense research in recent years. Research has shown that the junctional epithelial cells may play a much more active role in the innate defense mechanisms than previously assumed. They synthesize a variety of molecules directly involved in the combat against bacteria and their products. In addition, they express molecules that mediate the migration of polymorphonuclear leukocytes toward the bottom of the gingival sulcus. Periodontopathogens—such as Actinobacillus actinomycetemcomitans or, in particular, Porphyromonas gingivalis—have developed sophisticated methods to perturb the structural and functional integrity of the junctional epithelium. Research has focused on the direct effects of gingipains, cysteine proteinases produced by Porphyromonas gingivalis, on junctional epithelial cells. These virulence factors may specifically degrade components of the cell-to-cell contacts. This review will focus on the unique structural organization of the junctional epithelium, on the nature and functions of the various molecules expressed by its cells, and on how gingipains may attenuate the junctional epithelium’s structural and functional integrity.

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Crossref · 10.1177/154405910508400102

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Citations

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Research works printed but not linked: 3

  1. Schroeder HE (1977). Histopathology of the gingival sulcus. In: The borderland between caries and periodontal disease. Lehner T, editor. London: Academic Press, pp. 43–78.
  2. Schroeder HE, Attström R (1980). Pocket formation: an hypothesis. In: The borderland between caries and periodontal disease II. Lehner T, Cimasoni G, editors. London, New York: Academic Press/Grune & Stratton, pp. 99–123.
  3. Ten Cate AR (1998). Development of the periodontium. In: Oral histology. Development, structure, and function. Ten Cate AR, editor. St. Louis: Mosby, pp. 236–252.

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Metadata

Authors
Bosshardt, D. D., & Lang, N. P.
Affiliations
University of Bern (CH)
ORCID
Venue
Journal of Dental Research
Publisher
SAGE Publications
Published
2005-01
Volume
84
Issue
1
Pages
9-20
ISSN
  • 0022-0345 (ISSN-L)
  • 1544-0591
DOI
10.1177/154405910508400102
OpenAlex
W1970638674
Cited by
388
References
128
Citations by year
2026: 18 · 2025: 30 · 2024: 15 · 2023: 21 · 2022: 24 · 2021: 17 · 2020: 24 · 2019: 24 · 2018: 21 · 2017: 30 · 2016: 21 · 2015: 18 · 2014: 26 · 2013: 12 · 2012: 19
FWCI
1.80
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Journal of Dental Research (publishedVersion)
  • PubMed (publishedVersion)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Dentistry › Periodontics › Oral and gingival health research
  • Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
Keywords
junctional epithelium, periodontal disease, gingival lesions, innate immunity, antimicrobial defense, leukocyte migration, Porphyromonas gingivalis, gingipains, cysteine protease, Aggregatibacter actinomycetemcomitans, periodontal pathogens, cell-cell contact, gingival sulcus
MeSH terms
Gingipain Cysteine Endopeptidases, Animals, Cell Communication, Cysteine Endopeptidases, Epithelial Attachment, Hemagglutinins, Humans, Periodontal Pocket, Cell Adhesion Molecules, Cytokines, Porphyromonas gingivalis, Adhesins, Bacterial

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