The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Diabetes-enhanced Inflammation and Apoptosis—Impact on Periodontal Pathology
Abstract
Diabetes, particularly type 2 diabetes, is a looming health issue with many ramifications. Because diabetes alters the cellular microenvironment in many different types of tissues, it causes myriad untoward effects, collectively referred to as ’diabetic complications’. Two cellular processes affected by diabetes are inflammation and apoptosis. This review discusses how diabetes-enhanced inflammation and apoptosis may affect the oral environment. In particular, dysregulation of tumor necrosis factor and the formation of advanced glycation products, both of which occur at higher levels in diabetic humans and animal models, potentiate inflammatory responses and induce apoptosis of matrix-producing cells. The enhanced loss of fibroblasts and osteoblasts through apoptosis in diabetics could contribute to limited repair of injured tissue, particularly when combined with other known deficits in diabetic wound-healing. These findings may shed light on diabetes-enhanced risk of periodontal diseases.
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Citations
Cites
Global and societal implications of the diabetes epidemic
Zimmet, P., Alberti, K. G. M. M., & Shaw, J. (2001) · Nature · doi:10.1038/414782a · Cited by 5,883
Interferon-γ: an overview of signals, mechanisms and functions
Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603252 · Cited by 4,120
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543
Interleukin-6 induces cellular insulin resistance in hepatocytes.
Senn, J. J., Klover, P. J., Nowak, I. A., & Mooney, R. A. (2002) · Diabetes · doi:10.2337/diabetes.51.12.3391 · Cited by 883 · cited 1×
“Systemic levels of TNF- and IL-6 are elevated in diabetes and can directly promote insulin resistance (Senn et al., 2002; Borst, 2004).”
Background
Cited by
The Relationship Between Oral Health and Diabetes Mellitus
Lamster, I. B., Lalla, E., Borgnakke, W. S., & Taylor, G. W. (2008) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2008.0363 · Cited by 489
Metadata
- Authors
- Graves, D. T., Liu, R., Alikhani, M., Al-Mashat, H., & Trackman, P. C.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2006-01
- Volume
- 85
- Issue
- 1
- Pages
- 15-21
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2086132114
- Cited by
- 188
- References
- 4
- FWCI
- 11.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Graves, D. T., Liu, R., Alikhani, M., Al-Mashat, H., & Trackman, P. C. (2006). Diabetes-enhanced Inflammation and Apoptosis—Impact on Periodontal Pathology. Journal of Dental Research. https://doi.org/10.1177/154405910608500103
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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