The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
In vivo Preservation of the Hybrid Layer by Chlorhexidine
Abstract
Host-derived proteases have been reported to degrade the collagen matrix of incompletely-resin-infiltrated dentin. This study tested the hypothesis that interfacial degradation of resin-dentin bonds may be prevented or delayed by the application of chlorhexidine (CHX), a matrix metalloproteinase inhibitor, to dentin after phosphoric acid-etching. Contralateral pairs of resin-bonded Class I restorations in non-carious third molars were kept under intra-oral function for 14 months. Preservation of resin-dentin bonds was assessed by microtensile bond strength tests and TEM examination. In vivo bond strength remained stable in the CHX-treated specimens, while bond strength decreased significantly in control teeth. Resin-infiltrated dentin in CHX-treated specimens exhibited normal structural integrity of the collagen network. Conversely, progressive disintegration of the fibrillar network was identified in control specimens. Auto-degradation of collagen matrices can occur in resin-infiltrated dentin, but may be prevented by the application of a synthetic protease inhibitor, such as chlorhexidine.
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Citations
Cites
The role of matrix metalloproteinases (MMPs) in human caries
Chaussain-Miller, C., Fioretti, F., Goldberg, M., & Menashi, S. (2006) · Journal of Dental Research · doi:10.1177/154405910608500104 · Cited by 481
The effects of MMP inhibitors on human salivary MMP activity and caries progression in rats
Sulkala, M., Wahlgren, J., Larmas, M., Sorsa, T., Teronen, O., Salo, T., & Tjäderhane, L. (2001) · Journal of Dental Research · doi:10.1177/00220345010800061301 · Cited by 185
Self-citation
Cited by
Tjäderhane, L., Buzalaf, M. A. R., Carrilho, M., & Chaussain, C. (2015) · Caries Research · doi:10.1159/000363582 · Cited by 2,306
Self-citationLimitations in bonding to dentin and experimental strategies to prevent bond degradation
Liu, Y., Tjäderhane, L., Breschi, L., Mazzoni, A., Li, N., Mao, J., Pashley, D. H., & Tay, F. R. (2011) · Journal of Dental Research · doi:10.1177/0022034510391799 · Cited by 665
Self-citationRole of dentin MMPs in caries progression and bond stability
Mazzoni, A., Tjäderhane, L., Checchi, V., Di Lenarda, R., Salo, T., Tay, F. R., Pashley, D. H., & Breschi, L. (2015) · Journal of Dental Research · doi:10.1177/0022034514562833 · Cited by 429
Self-citationThe inhibitory effects of quaternary ammonium methacrylates on soluble and matrix-bound MMPs
Tezvergil-Mutluay, A., Agee, K. A., Uchiyama, T., Imazato, S., Mutluay, M. M., Cadenaro, M., Breschi, L., Nishitani, Y., Tay, F. R., & Pashley, D. H. (2011) · Journal of Dental Research · doi:10.1177/0022034510389472 · Cited by 182
Self-citationOxidized Dopamine Acrylamide Primer to Achieve Durable Resin–Dentin Bonding
Wu, L., Shao, H., Tao, Y., Wu, J., Wang, X., Nian, Q., Zheng, S., Cao, C. Y., Zhao, Y., Zhou, Z., et al. (2023) · Research · doi:10.34133/research.0101 · Cited by 19
Metadata
- Authors
- Carrilho, M. R. O., Geraldeli, S., Tay, F., de Goes, M. F., Carvalho, R. M., Tjäderhane, L., Reis, A. F., Hebling, J., Mazzoni, A., Breschi, L., & Pashley, D.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2007-06
- Volume
- 86
- Issue
- 6
- Pages
- 529-533
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2170055853
- Cited by
- 613
- References
- 2
- FWCI
- 50.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Carrilho, M. R. O., Geraldeli, S., Tay, F., de Goes, M. F., Carvalho, R. M., Tjäderhane, L., Reis, A. F., Hebling, J., Mazzoni, A., Breschi, L., & Pashley, D. (2007). In vivo Preservation of the Hybrid Layer by Chlorhexidine. Journal of Dental Research. https://doi.org/10.1177/154405910708600608
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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