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HISTOCHEMICAL AND ULTRASTRUCTURAL DEMONSTRATION OF γ-GLUTAMYL TRANSPEPTIDASE ACTIVITY
Abstract
A simultaneous coupling azo dye method for the histochemical demonstration of γ-glutamyl transpeptidase activity using the new substrate γ-glutamyl-4-methoxy-2-naphthylamide has been described. The method appears superior to previously reported methods for γ-glutamyl transpeptidase activity and can easily be modified for the electron microscopic localization of the enzyme by bridging osmium to the copper chelate of the azo dye via thiocarbohydrazide. The optimum conditions for the histochemical reaction were developed and the distribution of enzymatic activity in the tissues of the rat is described for light microscopy and with rat pancreas for electron microscopy. The electron-opaque deposits were seen in the endoplasmic reticulum in the vicinity of the zymogen granules in the apical portion of the acinar cell.
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Citations
Cited by
Wu, J. C., Merlino, G., & Fausto, N. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.674 · Cited by 317
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Schäfer, M., Dütsch, S., auf dem Keller, U., Navid, F., Schwarz, A., Johnson, D. A., Johnson, J. A., & Werner, S. (2010) · Genes & Development · doi:10.1101/gad.568810 · Cited by 175
Grappone, C., Pinzani, M., Parola, M., Pellegrini, G., Caligiuri, A., DeFranco, R., Marra, F., Herbst, H., Alpini, G., & Milani, S. (1999) · Journal of Hepatology · doi:10.1016/s0168-8278(99)80169-x · Cited by 133
Ultrastructural Cytochemistry of Blood-Brain Barrier Endothelia
Vorbrodt, A. W. (1988) · Progress in Histochemistry and Cytochemistry · doi:10.1016/s0079-6336(88)80001-9 · Cited by 108
Mereto, E., Brambilla Campart, G., Ghia, M., & Petrogalli, F. (1990) · Cancer Letters · doi:10.1016/0304-3835(90)90011-l · Cited by 5
Metadata
- Authors
- RUTENBURG, A. M., KIM, H., FISCHBEIN, J. W., HANKER, J. S., WASSERKRUG, H. L., & SELIGMAN, A. M.
- Venue
- Journal of Histochemistry & Cytochemistry
- Publisher
- SAGE Publications
- Published
- 1969-08
- Volume
- 17
- Issue
- 8
- Pages
- 517-526
- ISSN
- 0022-1554 (ISSN-L)
- 1551-5044
- OpenAlex
- W2072891772
- Cited by
- 942
- References
- 0
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: HISTOCHEMICAL AND ULTRASTRUCTURAL DEMONSTRATION OF γ-GLUTAMYL TRANSPEPTIDASE ACTIVITY. https://app.cochat.ai/papers/10.1177/17.8.517
- The paper
- RUTENBURG, A. M., KIM, H., FISCHBEIN, J. W., HANKER, J. S., WASSERKRUG, H. L., & SELIGMAN, A. M. (1969). HISTOCHEMICAL AND ULTRASTRUCTURAL DEMONSTRATION OF γ-GLUTAMYL TRANSPEPTIDASE ACTIVITY. Journal of Histochemistry & Cytochemistry. https://doi.org/10.1177/17.8.517
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
