Effect of menopausal hormone therapy on components of the metabolic syndrome
Open accessAbstract
The world population is aging, and women will spend an increasing share of their lives in a postmenopausal state that predisposes to metabolic dysfunction. Thus, the prevalence of metabolic syndrome (MetS) in women is likely to increase dramatically. This article summarizes the effects of menopause in predisposing to components of MetS including visceral obesity, dyslipidemia, type 2 diabetes (T2D) and hypertension (HTN). We also summarize the effects of menopausal hormone therapy (MHT) in reversing these metabolic alterations and discuss therapeutic advances of novel menopausal treatment on metabolic function.
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MHT reduces HOMA-IR in postmenopausal women, with a nearly 3-fold greater benefit in postmenopausal women with type 2 diabetes.
“MHT has also been shown to reduce homeostatic model assessment of insulin resistance (HOMA-IR) in postmenopausal women, and with a nearly 3-fold greater benefit in postmenopausal women with T2D (204, 208).”
From Metabolic impact of endogenously produced estrogens by adipose tissue in females and males across the lifespan (2025) · cites this paper as [208]
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References 84 · Cited by 44
- Authors
- Lovre, D., Lindsey, S. H., & Mauvais-Jarvis, F.
- Affiliations
- Tulane University (US)
- Division of Endocrinology and Metabolism, Tulane University Health Sciences Center, 1430 Tulane Avenue SL-53, New Orleans, LA 70112, USA
- Venue
- Therapeutic Advances in Cardiovascular Disease
- Publisher
- SAGE Publications
- Published
- 2016-07-31
- Volume
- 11
- Issue
- 1
- Pages
- 33-43
- ISSN
- 1753-9447 (ISSN-L)
- 1753-9455
- PMC
- PMC5933555
- OpenAlex
- W2407239416
- Cited by
- 44
- References
- 84
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 8 · 2023: 5 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 1
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Therapeutic Advances in Cardiovascular Disease (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- hormone replacement therapy, metabolic syndrome, menopause, visceral obesity, dyslipidemia, type 2 diabetes, hypertension, postmenopausal women, metabolic dysfunction
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