Danger signals in stroke and their role on microglia activation after ischemia
Open accessAbstract
Ischemic stroke is a major cause of death. Besides the direct damage resulting from oxygen and glucose deprivation, sterile inflammation plays a pivotal role in increasing cellular death. Damaged-associated molecular patterns (DAMPs) are passively released from dying cells and activate the innate immune system. Thus, they take part in the direct and rapid activation of the inflammatory response after stroke onset. In this review the role of the most important DAMPs, high mobility group box 1, heat and cold shock proteins, purines, and peroxiredoxins, are addressed. Moreover, intracellular pathways activated by DAMPs in microglia are illuminated.
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Neuronal damage is an important triggering factor for NOX activation in microglia, likely mediated by DAMPs originating from neurones in both acute injury and chronic neuroinflammation.
“Neuronal damage is an important triggering factor for NOX activation in microglia, likely mediated by DAMPs originating from neurones in both acute injury and chronic neuroinflammation [89,90].”
From ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease (2020) · cites this paper as [89]
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References 131 · Cited by 321
- Authors
- Gülke, E., Gelderblom, M., & Magnus, T.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- Corresponding author
- Magnus, Tim
- Venue
- Therapeutic Advances in Neurological Disorders
- Publisher
- SAGE Publications
- Published
- 2018-01-01
- Volume
- 11
- Pages
- 1756286418774254-1756286418774254
- ISSN
- 1756-2856 (ISSN-L)
- 1756-2864
- PMC
- PMC5968660
- OpenAlex
- W2804015886
- Cited by
- 321
- References
- 131
- Citations by year
- 2026: 35 · 2025: 45 · 2024: 69 · 2023: 44 · 2022: 35 · 2021: 37 · 2020: 37 · 2019: 17 · 2018: 2
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Therapeutic Advances in Neurological Disorders (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Hermann and Lilly Schilling foundation for medical research
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- ischemic stroke, microglial activation, sterile inflammation, HMGB1, heat shock proteins, cold shock proteins, purines, peroxiredoxin, innate immune response, oxygen-glucose deprivation, neuroinflammation
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