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Aromatic Hydroxyl Group Plays a Critical Role in Antibacterial Activity of the Curcumin Analogues
Open accessAbstract
The aim of this study was to investigate the role of the aromatic substituents of the curcumin scaffold on the antibacterial activity of the resulting curcumin analogues. Six curcumin analogues with different aromatic substituents were prepared and their antibacterial activities were evaluated against two Gram-positive and four Gram-negative bacteria. The structure-activity relationship study demonstrated that antibacterial activity of the curcumin analogues was critically dependent upon the aromatic hydroxyl group. Thus, hydroxycurcumin with an additional aromatic hydroxyl group on the curcumin scaffold showed antibacterial activity against all six pathogens tested and it remained effective even against ampicillin-resistant Enterobacter cloacae. Along with the previously reported antioxidative effect, the broad-spectrum antibacterial activity of the hydroxycurcumin warrants further investigation of its biological activity as well as extensive structure-activity relationship study of the curcumin analogues with various aromatic substituents.
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“These alterations can cause polymerization, cleavage, or isomerization of phenolic molecules, which diminish their solubility and reduce the availability of free hydroxyl groups responsible for radical scavenging and microbial inhibition (Kim et al., 2012; Mousavi Khaneghah et al., 2018).”
From Influence of Extraction Parameters on Bioactive Compounds and Antimicrobial Activity of Banana Peel Using Ethanol-Water Solvent (2026) · cites this paper as Kim et al., 2012
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“Conversely, extraction at elevated temperatures (60 °C) or prolonged durations (90 minutes) leads to thermal degradation and oxidative modifications of phenolic structures.”
From Influence of Extraction Parameters on Bioactive Compounds and Antimicrobial Activity of Banana Peel Using Ethanol-Water Solvent (2026) · cites this paper as Kim et al., 2012
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İmece, A. (2026) · Journal of the Institute of Science and Technology · doi:10.21597/jist.1745262
Metadata
- Authors
- Kim, M. K., Park, J. C., & Chong, Y.
- Affiliations
- Konkuk University (KR)
- Rural Development Administration (KR)
- Corresponding author
- Chong, Youhoon
- Venue
- Natural Product Communications
- Publisher
- SAGE Publications
- Published
- 2012-01
- Volume
- 7
- Issue
- 1
- Pages
- 57-8
- ISSN
- 1555-9475 (ISSN-L)
- 1934-578X
- OpenAlex
- W2419330786
- Cited by
- 30
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 5 · 2018: 2 · 2017: 2 · 2015: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Locations
- Natural Product Communications (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
- Physical Sciences › Chemistry › Organic Chemistry › Heterocyclic Compound Synthesis and Bioactivity
- Keywords
- curcumin derivatives, antibacterial activity, aromatic hydroxyl groups, structure-activity relationship, aromatic substituents, Gram-positive bacteria, Gram-negative bacteria, antimicrobial resistance
- MeSH terms
- Anti-Bacterial Agents, Curcumin, Structure-Activity Relationship
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- The paper
- Kim, M. K., Park, J. C., & Chong, Y. (2012). Aromatic Hydroxyl Group Plays a Critical Role in Antibacterial Activity of the Curcumin Analogues. Natural Product Communications. https://doi.org/10.1177/1934578x1200700120
