Dosage of Bioactive Molecules in the Nutricosmeceutical Helix aspersa Muller Mucus and Formulation of New Cosmetic Cream with Moisturizing Effect
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The present study was carried out to provide the allantoin and glycolic acid contents in the Helix aspersa Muller mucus of common Campania land (Italy) by using chromatographic method. The study continued with the formulation of a snail mucus cosmetic cream, whose ability to hydrate the skin was evaluated comparing the skin hydration and trans-epidermal water loss (TEWL) effects of a stable cosmetic preparation. The skin TEWL and skin hydration effects were measured by TEWAMETER and corneometer probe, respectively, at the beginning, after 1 hour, and 24 hours.
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Corneometry showed that all creams containing 2%, 5%, and 10% snail mucus enhanced skin hydration compared to the cream without snail mucus, and the higher the concentration of snail mucus in the creams, the better the hydration of the skin in women.
“The results of corneometry showed that all the creams (2%, 5%, 10%) enhanced skin hydration compared to the cream without the snail mucus. The higher the concentration of snail mucus in the creams, the better the hydration of the skin in women [55].”
From Chemical Variability and Biological Potential of Cornu aspersum Mucus as a Source for the Development of New Cosmetic and Pharmaceutical Products (2025) · cites this paper as [55]
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Experimental — accuracy not yet measuredCosmetic products containing snail mucus are being developed to decrease stretch marks, acne, and pigment spots; soothe and moisturize the skin; eliminate signs of photoaging and reduce damage caused by free radicals; fight age-related skin changes; and recover gray hair color.
“Cosmetic products in different forms containing snail mucus (ampoules, creams, serums, etc.) are being developed that are designed to decrease stretch marks, acne, and pigment spots; to soothe and moisturize the skin; to eliminate signs of photoaging and reduce damage caused by free radicals; to fight age-related skin changes; to recover gray hair color; etc.”
From Chemical Variability and Biological Potential of Cornu aspersum Mucus as a Source for the Development of New Cosmetic and Pharmaceutical Products (2025) · cites this paper as [55]
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredMoisturizing cosmetic creams based on Prunus amygdalus dulcis oil and Triticum vulgare germ oil containing 0%, 2%, 5%, and 10% C. aspersum mucus provided the desired moisturizing effect.
“Based on the evaluation of skin hydration after the application of the moisturizing cosmetic creams on the basis of Prunus amygdalus dulcis oil and Triticum vulgare germ oil, which contained 0% (a control sample), 2%, 5%, and 10% of the C. aspersum mucus, the creams provided the desired moisturizing effect [55].”
From Chemical Variability and Biological Potential of Cornu aspersum Mucus as a Source for the Development of New Cosmetic and Pharmaceutical Products (2025) · cites this paper as [55]
The Formulation development section describes creams with 0% (placebo), 2%, 5%, and 10% mucus, and Table 5 reports hydration measurements for all four. The Measurement of Skin Hydration section reports improved hydration for the mucus-containing formulations, but the Conclusion identifies only the 2% cream as giving a “desirable moisturizing action”; it does not make that conclusion for every cream, including the placebo. (LLM, conf=0.84)
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Research works printed but not linked: 14
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- Conte R. Recent advances on nano delivery of helix mucus pharmacologically active components. Inter J Nano Dimens. 2016;7(3):181-185.
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- Bernstein EF, Lee J, Brown DB, Yu R, Van Scott E. Glycolic acid treatment increases type I collagen mRNA and hyaluronic acid content of human skin. Dermatol Surg. 2001;27(5):429-433.
- Inan S, Oztukcan S, Vatansever S, et al. Histopathological and ultrastructural effects of glycolic acid on rat skin. Acta Histochem. 2006;108(1):37-47.
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The new challenge of green cosmetics: natural food ingredients for cosmetic formulations
Dini, I., & Laneri, S. (2021) · Molecules · doi:10.3390/molecules26133921 · Cited by 217 · see citing works
Self-citationHudz, N., Turkina, V., Alyokhina, T., Motyka, O., Chemerys, N., Rumynska, T., Lozynskyi, A., Jasicka-Misiak, I., & Kobylinska, L. (2025) · Molecules · doi:10.3390/molecules30214197 · Cited by 4 · see citing works
- Authors
- Laneri, S., Lorenzo, R. D., Sacchi, A., & Dini, I.
- Affiliations
- University of Naples Federico II (IT)
- Corresponding author
- Dini, Irene
- Venue
- Natural Product Communications
- Publisher
- SAGE Publications
- Published
- 2019-08
- Volume
- 14
- Issue
- 8
- ISSN
- 1555-9475 (ISSN-L)
- 1934-578X
- OpenAlex
- W2966214880
- Cited by
- 27
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 9
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Natural Product Communications (publishedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Agricultural and Biological Sciences › Insect Science › Mollusks and Parasites Studies
- Health Sciences › Health Professions › Complementary and Manual Therapy › Therapeutic Uses of Natural Elements
- Keywords
- snail mucus, nutricosmetics, allantoin, glycolic acid, cosmetic cream formulation, skin hydration, transepidermal water loss, moisturizing effect, bioactive compounds
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