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Cited by 9Phytochemical compounds biological activitiesPhytochemistry and Biological ActivitiesTuberculosis Research and Epidemiology

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Antimycobacterial Activity of the Extract and Isolated Compounds From the Stem Bark of Zanthoxylum leprieurii Guill. and Perr.

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Oloya, Benson, Namukobe, Jane, Heydenreich, Matthias, Ssengooba, Willy, Schmidt, Bernd, Byamukama, Robert·2021·Natural Product Communications
DOI 10.1177/1934578x211035851
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Abstract

Zanthoxylum leprieurii Guill. and Perr. (Rutaceae) stem bark is used locally in Uganda for treating tuberculosis (TB) and cough-related infections. Lupeol (1), sesamin (2), trans-fagaramide (3), arnottianamide (4), ( S)-marmesinin (5), and hesperidin (6) were isolated from the chloroform/methanol (1:1) extract of Z. leprieurii stem bark. Their structures were elucidated using spectroscopic techniques and by comparison with literature data. Furthermore, the extract and isolated compounds were subjected to antimycobacterial activity. The extract exhibited moderate activity against the susceptible (H 37 Rv) TB strain, but weak activity against the multidrug resistant (MDR)-TB strain with minimum inhibitory concentrations (MICs) of 586.0 and 1172.0 μg/mL, respectively. Compound 3 (trans-fagaramide) showed significant antimycobacterial activity against the susceptible (H 37 Rv) TB strain (MIC 6 μg/mL), but moderate activity against the MDR-TB strain (MIC 12.2 μg/mL). Compounds 2, 5, 6, and 1 showed moderate activities against the susceptible (H 37 Rv) strain (MIC 12.2-98.0 μg/mL) and moderate to weak activities against the MDR-TB strain (MIC 24.4-195.0 μg/mL). This study reports for the first time the isolation of compounds 1 to 6 from the stem bark of Z leprieurii. trans-Fagaramide (3) may present a vital template in pursuit of novel and highly effective TB drugs.

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Metadata

Authors
Oloya, B., Namukobe, J., Heydenreich, M., Ssengooba, W., Schmidt, B., & Byamukama, R.
Affiliations
  • Muni University (UG)
  • Makerere University (UG)
  • University of Potsdam (DE)
Corresponding author
Oloya, Benson
ORCID
Venue
Natural Product Communications
Publisher
SAGE Publications
Published
2021-08
Volume
16
Issue
8
ISSN
  • 1555-9475 (ISSN-L)
  • 1934-578X
DOI
10.1177/1934578x211035851
OpenAlex
W3194986554
Cited by
9
References
1
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 4
FWCI
0.47
Type
journal article
Language
en
Open access
Licence
Locations
  • Natural Product Communications (publishedVersion, cc-by-nc)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • publish.UP (University of Potsdam) (submittedVersion, cc-by-nc)
Funders
Deutscher Akademischer Austauschdienst (DAAD) In-Country Scholarship, Uganda 2016 (91560246)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Phytochemical compounds biological activities
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
  • Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Keywords
Zanthoxylum leprieurii, stem bark, antimycobacterial activity, tuberculosis, multidrug-resistant tuberculosis, lupeol, sesamin, hesperidin, natural product isolation, Rutaceae, Mycobacterium tuberculosis H37Rv

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