Drug-induced supersensitivity psychosis revisited: characteristics of relapse in treatment-compliant patients
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Background: An association between abnormal involuntary movements and psychotic relapse was previously reported in a group of patients compliant with antipsychotic medication ( Fallon and Dursun 2011 ). This was interpreted as the presence of an antipsychotic medication-induced supersensitivity psychosis. Method: From the results of that study and the Chouinard diagnostic criteria for supersensitivity psychosis an abbreviated diagnostic checklist was developed to identify the phenomenon. In the present study the checklist was used on a larger sample of medication-compliant individuals experiencing a psychotic relapse. Results: The checklist demonstrated its utility by identifying a cause of relapse in 70% (29/41) of patients. Furthermore, it identified the presence of supersensitivity psychosis in 39% (16/41) of patients. This study also replicated a number of findings from the previous paper supporting the idea that supersensitivity psychosis is one cause of relapse in psychosis. Discussion: These results suggested that clinicians should exercise caution in prescribing and may have to augment treatment with other agents or switch to low dopamine-affinity antipsychotics.
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Persistent post-withdrawal disorders, defined as rebound symptoms and/or new withdrawal symptoms and/or emerging new psychotic symptoms of another type persisting longer than 6 weeks, have been described after discontinuation of antipsychotics.
“Persistent post-withdrawal disorders, that is a condition in which rebound symptoms and/or new withdrawal symptoms and/or emerging new psychotic symptoms of another type, such as disorganized behavior, persist longer than 6 weeks, have been described after discontinuation of antipsychotics.”
From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [150]
Two specific persistent post-withdrawal disorders, persistent post-withdrawal tardive dyskinesia and persistent post-withdrawal supersensitivity psychosis, have been well described.
“2 specific persistent post-withdrawal disorders, named persistent post-withdrawal tardive dyskinesia and persistent post-withdrawal supersensitivity psychosis, have been well described [21, 22, 150, 151].”
From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [150]
Chouinard et al. concluded that 2 persistent post-withdrawal disorders, tardive dyskinesia and supersensitivity psychosis, were specifically induced by antipsychotics.
“and that 2 persistent post-withdrawal disorders, tardive dyskinesia and supersensitivity psychosis, were specifically induced by antipsychotics [21, 22, 150, 151].”
From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [150]
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References 19 · Cited by 47
- Authors
- Fallon, P., Dursun, S., & Deakin, B.
- Corresponding author
- Fallon, Paul
- Dursun, Serdar
- ORCID
- Dursun, Serdar
- Venue
- Therapeutic Advances in Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2011-12-05
- Volume
- 2
- Issue
- 1
- Pages
- 13-22
- ISSN
- 2045-1253 (ISSN-L)
- 2045-1261
- PMC
- PMC3736929
- OpenAlex
- W2170824680
- Cited by
- 47
- References
- 19
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 2 · 2013: 1
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Therapeutic Advances in Psychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Salford Institutional Repository (University of Salford) (submittedVersion, cc-by)
- Research Explorer (The University of Manchester) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- psychotic relapse, abnormal involuntary movements, diagnostic checklist, treatment-resistant psychosis, antipsychotic switching
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