Cited by 273Menopause: Health Impacts and TreatmentsOvarian function and disordersHormonal and reproductive studies

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Cardiovascular disease risk in women with premature ovarian insufficiency: A systematic review and meta-analysis

Roeters van Lennep, Jeanine E, Heida, Karst Y, Bots, Michiel L, Hoek, Annemieke, on behalf of the collaborators of the Dutch Multidisciplinary Guideline Development Group on Cardiovascular Risk Management after Reproductive Disorders·2016·European Journal of Preventive Cardiology

DOI 10.1177/2047487314556004

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Abstract

AIMS: The purpose of this review was to assess the relationship between premature ovarian insufficiency (POI), defined as natural menopause <40 years, and risk of ischaemic heart disease (IHD), stroke and overall cardiovascular disease (CVD). METHODS AND RESULTS: We performed a systematic search in PubMed (1966-2012), EMBASE (1980-2012). Studies were included if they were prospective, follow-up>3 years, assessment of age menopause <40 years, and incident cases of fatal or nonfatal IHD, stroke, or overall CVD. Relative risks (RRs) and 95% confidence interval (CI) were pooled using a random-effect model. Overall, 10 observational studies were identified, comprising 190,588 women (follow-up 4-37 years) with 9440 events (2026 events for IHD (seven studies) and 6438 events for stroke (seven studies) and 976 for total CVD (two studies). POI was assessed by questionnaire and incident cases through certification and event registers. POI was related to an increased risk of developing or dying from IHD (hazard ratio (HR) 1.69, 95% CI 1.29-2.21, p = 0.0001) and total CVD (HR 1.61, 95% CI 1.22-2.12, p = 0.0007). No relation was found for stroke (HR 1.03, 0.88-1.19, p = 0.74). We found no evidence for heterogeneity. CONCLUSION: POI is an independent though modest risk factor of IHD and overall CVD but not of stroke. Because of the limited impact of POI on CVD risk compared to classical cardiovascular risk factors, it is unlikely that POI will be implemented as modifier of cardiovascular risk classification.

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Authors: Roeters van Lennep, J. E., Heida, K. Y., Bots, M. L., Hoek, A., & on behalf of the collaborators of the Dutch Multidisciplinary Guideline Development Group on Cardiovascular Risk Management after Reproductive Disorders
Affiliations: Department of Internal Medicine, Erasmus MC, the Netherlands
University Medical Center Utrecht (NL)
University of Groningen (NL)
ORCID: Bots, Michiel L
Hoek, Annemieke
Venue: European Journal of Preventive Cardiology
Publisher: Oxford University Press (OUP)
Published: 2014-10-20
Volume: 23
Issue: 2
Pages: 178-186
ISSN: 2047-4873 (ISSN-L)
2047-4881
DOI: 10.1177/2047487314556004
OpenAlex: W2120592625
Cited by: 273
References: 31
Citations by year: 2026: 24 · 2025: 29 · 2024: 23 · 2023: 29 · 2022: 34 · 2021: 25 · 2020: 24 · 2019: 29 · 2018: 21 · 2017: 16 · 2016: 7 · 2015: 11 · 2014: 1
FWCI: 1.86
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: European Journal of Preventive Cardiology (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Utrecht University Repository (Utrecht University) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords: premature ovarian insufficiency, cardiovascular risk, ischemic heart disease, stroke, women, natural menopause, cardiovascular risk factors, cardiovascular risk classification
MeSH terms: Cardiovascular Diseases, Female, Humans, Risk Factors, Primary Ovarian Insufficiency, Stroke

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Cardiovascular disease risk in women with premature ovarian insufficiency: A systematic review and meta-analysis

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