The role of lipopolysaccharide-induced cell signalling in chronic inflammation
Open accessAbstract
Lipopolysaccharide (LPS) is the main structural component of the outer membrane of most Gram-negative bacteria and has diverse immunostimulatory and procoagulant effects. Even though LPS is well described for its role in the pathology of sepsis, considerable evidence demonstrates that LPS-induced signalling and immune dysregulation are also relevant in the pathophysiology of many diseases, characteristically where endotoxaemia is less severe. These diseases are typically chronic and progressive in nature and span broad classifications, including neurodegenerative, metabolic, and cardiovascular diseases. This Review reappraises the mechanisms of LPS-induced signalling and emphasises the crucial contribution of LPS to the pathology of multiple chronic diseases, beyond conventional sepsis. This perspective asserts that new ways of approaching chronic diseases by targeting LPS-driven pathways may be of therapeutic benefit in a wide range of chronic inflammatory conditions.
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LPS may alter gut homeostasis, inflammation, and permeability while activating various immune cells, including macrophages, neutrophils, and dendritic cells.
“LPS may alter gut homeostasis, inflammation, and permeability (91, 92) while activating various immune cells, including macrophages, neutrophils, and dendritic cells.”
From Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis (2023) · cites this paper as [91]
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References 180 · Cited by 315
Research works printed but not linked: 1
- [68]Freudenberg MA Galanos C. Metabolism of LPS in vivo. In: Morrison DC Ryan JL (eds) Bacterial Endotoxic Lipopolysaccharides, Vol 2: Immunopharmacology and Pathophysiology. 275–294, Boca Raton: CRC Press, 1992.
- Authors
- Page, M. J., Kell, D. B., & Pretorius, E.
- Affiliations
- Stellenbosch University (ZA)
- University of Liverpool (GB)
- Corresponding author
- Pretorius, Etheresia
- Venue
- Chronic Stress
- Publisher
- SAGE Publications
- Published
- 2022-01
- Volume
- 6
- Pages
- 24705470221076390-24705470221076390
- ISSN
- 2470-5470 (ISSN-L)
- PMC
- PMC8829728
- OpenAlex
- W4210844311
- Cited by
- 315
- References
- 180
- Citations by year
- 2026: 76 · 2025: 90 · 2024: 77 · 2023: 51 · 2022: 21
- FWCI
- 6.28
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Chronic Stress (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion, cc-by-nc)
- Funders
- Novo Nordisk Fonden (NNF20CC0035580)
- UK Biotechnology and Biological Sciences Research Council (BB/L025752/1)
- Medical Research Council (MRC) of South Africa (Self-Initiated Research Program)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- lipopolysaccharide, endotoxemia, chronic inflammation, Gram-negative bacteria, immune dysregulation, neurodegenerative diseases, metabolic disorders, cardiovascular disease
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