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Suppression of endogenous avidin-binding activity in tissues and its relevance to biotin-avidin detection systems.
Open accessAbstract
As biotin-avidin systems continue to be developed for applications involving single cells, cell suspensions, and especially tissue sections, the need arises for a method of blocking endogenous avidin-binding activity. One such method is described and its proposed mechanism is discussed. Utilizing this method, endogenous avidin-binding activity was detected and suppressed in selected human and murine tissues, thus facilitating the interpretation of specific immunohistochemical staining utilizing hybridoma monoclonal antibodies in a biotin-avidin-horseradish peroxidase detection system.
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Cited by
The avidin-biotin complex in bioanalytical applications
Wilchek, M., & Bayer, E. A. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90120-0 · Cited by 894
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531
Multiple Immunoenzyme Staining: Methods and Visualizations for the Observation With Spectral Imaging
Loos, C. M. V. D. (2008) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2007.950170 · Cited by 232
Metadata
- Authors
- Wood, G. S., & Warnke, R.
- Venue
- Journal of Histochemistry & Cytochemistry
- Publisher
- SAGE Publications
- Published
- 1981-10
- Volume
- 29
- Issue
- 10
- Pages
- 1196-1204
- ISSN
- 0022-1554 (ISSN-L)
- 1551-5044
- OpenAlex
- W2134284956
- Cited by
- 539
- References
- 0
- FWCI
- 7.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Suppression of endogenous avidin-binding activity in tissues and its relevance to biotin-avidin detection systems. https://app.cochat.ai/papers/10.1177/29.10.7028859
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- Wood, G. S., & Warnke, R. (1981). Suppression of endogenous avidin-binding activity in tissues and its relevance to biotin-avidin detection systems. Journal of Histochemistry & Cytochemistry. https://doi.org/10.1177/29.10.7028859
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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