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Cited by 210

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Distribution of myoepithelial cells and basement membrane proteins in the resting, pregnant, lactating, and involuting rat mammary gland.

Open access
Warburton, M J, Mitchell, D, Ormerod, E J, Rudland, P·1982·Journal of Histochemistry & Cytochemistry

Abstract

Using antisera to specific proteins, the localization of the rat mammary parenchymal cells (both epithelial and myoepithelial), the basement membrane, and connective tissue components has been studied during the four physiological stages of the adult rat mammary gland, viz. resting, pregnant, lactating, and involuting glands. Antisera to myosin and prekeratin were used to localize myoepithelial cells, antisera to rat milk fat globule membrane for epithelial cells, antisera to laminin and type IV collagen to delineate the basement membrane and antisera to type I collagen and fibronectin as markers for connective tissue. In the resting, virgin mammary gland, myoepithelial cells appear to form a continuous layer around the epithelial cells and are in turn surrounded by a continuous basement membrane. Antiserum to fibronectin does not delineate the basement membrane in the resting gland. The ductal system is surrounded by connective tissue. Only the basal or myoepithelial cells in the terminal end buds of neonatal animals demonstrate cytoplasmic staining for basement membrane proteins, indicating active synthesis of these proteins during this period. In the secretory alveoli of the lactating rat, the myoepithelial cells no longer appear to form a continuous layer beneath the epithelial cells and in many areas the epithelial cells appear to be in contact with the basement membrane. The basement membrane in the lactating gland is still continuous around the ducts and alveoli. In the lactating gland, fibronectin appears to be located in the basement membrane region in addition to being a component of the stroma. During involution, the alveoli collapse, and appear to be in a state of dissolution. The basement membrane is thicker and is occasionally incomplete, as also are the basket-like myoepithelial structures. Basement membrane components can also be demonstrated throughout the collapsed alveoli.

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Metadata

Authors
Warburton, M. J., Mitchell, D., Ormerod, E. J., & Rudland, P.
Venue
Journal of Histochemistry & Cytochemistry
Published
1982-07
Volume
30
Issue
7
Pages
667-676
ISSN
  • 0022-1554 (ISSN-L)
  • 1551-5044
OpenAlex
W2089966961
Cited by
210
References
1
FWCI
8.37
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Distribution of myoepithelial cells and basement membrane proteins in the resting, pregnant, lactating, and involuting rat mammary gland. https://app.cochat.ai/papers/10.1177/30.7.6179984
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Warburton, M. J., Mitchell, D., Ormerod, E. J., & Rudland, P. (1982). Distribution of myoepithelial cells and basement membrane proteins in the resting, pregnant, lactating, and involuting rat mammary gland. Journal of Histochemistry & Cytochemistry. https://doi.org/10.1177/30.7.6179984

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.