Role of nitric oxide in a progressive neurodegeneration model of Parkinson's disease in the rat
Open accessAbstract
This study was undertaken to investigate the nitric oxide synthase (NOS) activity in the striatum following 6-hydroxydopamine (6-OHDA) induced neurodegeneration in rats. Constitutive NOS (cNOS) activity remained unaltered at 3, 7 and 14 days after lesion, while a 43% and 45% decrease was observed at 30 and 50 days, respectively. Inducible NOS (iNOS) activity was detected only on the 3rd day after lesion and not in subsequent days or the control striatum. N(G)-nitro-L-arginine methyl ester (L-NAME) pretreatment blocked the amphetamine-induced rotations and inhibited the iNOS activity at the 3rd day after the 6-OHDA injection. L-NAME pretreatment also significantly restored the striatal dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) levels in 6-OHDA treated rats. Thus a possible role of nitric oxide in 6-OHDA induced neurodegeneration is suggested.
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NOS inhibition protected neurons from death in PD mouse models.
“NOS inhibition protected neuron from death in PD mouse models.464–467”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [464]
Cites
Liberatore, G. T., Jackson-Lewis, V., Vukosavic, S., Mandir, A. S., Vila, M., McAuliffe, W. G., Dawson, V. L., Dawson, T. M., & Przedborski, S. (1999) · Nature Medicine · doi:10.1038/70978 · Cited by 1,046 · see citing works
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Role of neuroinflammation in neurodegeneration development
Zhang, W., Xiao, D., Mao, Q., & Xia, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01486-5 · Cited by 1,668 · see citing works
- Authors
- Barthwal, M. K., Srivastava, N., & Dikshit, M.
- Affiliations
- Central Drug Research Institute (IN)
- Venue
- Redox Report
- Publisher
- Informa UK Limited
- Published
- 2001-10
- Volume
- 6
- Issue
- 5
- Pages
- 297-302
- ISSN
- 1351-0002 (ISSN-L)
- 1743-2928
- OpenAlex
- W2008520631
- Cited by
- 66
- References
- 1
- Citations by year
- 2024: 2 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Redox Report (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- nitric oxide, Parkinson's disease, 6-hydroxydopamine, neurodegeneration, inducible nitric oxide synthase, constitutive nitric oxide synthase, striatum, L-NAME, dopamine, DOPAC, homovanillic acid, amphetamine-induced rotation, neuroprotection
- MeSH terms
- Animals, Corpus Striatum, Disease Models, Animal, Dopamine, Enzyme Inhibitors, Homovanillic Acid, Male, Motor Activity, Nitric Oxide, Parkinson Disease, Parkinson Disease, Secondary, 3,4-Dihydroxyphenylacetic Acid, Oxidopamine, Rats, Sprague-Dawley, Disease Progression, Adrenergic Agents, Nitric Oxide Synthase, NG-Nitroarginine Methyl Ester, Rats, Nitric Oxide Synthase Type II
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