100 Years of peroxynitrite chemistry and 11 years of peroxynitrite biochemistry
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The paper on the unusual properties of a mixture of hydrogen peroxide and nitrous acid by Baeyer and Villiger from 1901 can be regarded as the first report on peroxynitrite. In 1990, Beckman and co-workers suggested that peroxynitrite, formed from the reaction of superoxide with nitrogen monoxide, could be a transient oxidizing species in vivo, a report that revolutionized investigations in the field of oxidative stress.
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The rate constant for the reaction of NO and O2 ̇̄ has been reported to be as high as 1.9 × 10^10 M−1 s−1, nearing the diffusion limit for reactions.
“The rate constant for the reaction of NO and O2˙̄ has been reported to be as high as 1.9 × 1010 m−1 s−1, nearing the diffusion limit for reactions (24).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [24]
The best studied reaction of NO with other free radicals is the very rapid reaction of NO with superoxide to form peroxynitrite.
“The best studied of these reactions is the very rapid reaction of NO with superoxide to form peroxynitrite (2, 21, 22, 24).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [24]
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References 33 · Cited by 41
Research works printed but not linked: 4
- Koppenol WH, Kissner R. Can O=NOOH undergo homolysis? Chem Res Toxicol 1998; 11: 87-90.
- ONOO -Peroxynitrite. In: Pietsch EHE, Kotowski A, Becke- Goehring M. Gmelin Handbook of Inorganic and Organometallic Chemistry; Nitrogen. Berlin, Springer, 1996; 344-358.
- Huie RE, Padmaja S. Reaction of NO • with O 2 •-. Free Radic Res Commun 1993; 18: 195-199.
- Fielden EM, Roberts PB, Bray RC et al. The mechanism of action of superoxide dismutase from pulse radiolysis and electron paramagnetic resonance. Biochem J 1974; 139: 49-60.
- Authors
- Koppenol, W. H.
- Affiliations
- ETH Zurich (CH)
- Corresponding author
- Koppenol, W.H.
- ORCID
- Koppenol, W.H.
- Venue
- Redox Report
- Publisher
- Informa UK Limited
- Published
- 2001-12
- Volume
- 6
- Issue
- 6
- Pages
- 339-341
- ISSN
- 1351-0002 (ISSN-L)
- 1743-2928
- OpenAlex
- W2060798920
- Cited by
- 41
- References
- 33
- Citations by year
- 2024: 2 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 1 · 2012: 6
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Redox Report (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- peroxynitrite, superoxide, nitric oxide, oxidative stress, reactive oxygen species, nitrosative stress, Baeyer-Villiger oxidation
- MeSH terms
- Biochemistry, Chemistry, Peroxynitrous Acid, History, 20th Century
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