In vivo and in vitro antioxidant activity and hepatoprotective properties of polyphenols from Halimeda opuntia(Linnaeus) Lamouroux
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Antioxidant activity and hepatoprotective properties of the aqueous extract and tetrahydrofuran-extracted phenolic fractions of Halimeda opuntia (Linnaeus) Lamouroux were investigated in rats with chemically induced liver injury. Total polyphenols were determined by using the Folin-Ciocalteau reagent. Liver damage was induced by CCl(4) and assessed by a histological technique. Reverse transcription/polymerase chain reaction (RT/PCR) analysis showed increased superoxide dismutase (SOD) and catalase (CAT) gene expression and activities in the group treated with free phenolic acid (FPA) fractions of H. opuntia, suggesting inducing effects on both enzymes. In addition, rats treated with FPA fractions displayed lower liver thiobarbituric acid reactive substance (TBARS) levels than those observed for rats in the CCl(4)-treated group. These data suggest that the phenolic fractions from H. opuntia may protect the liver against oxidative stress-inducing effects of chemicals by modulating its antioxidant enzymes and oxidative status.
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The hepatoprotective and antioxidant potential of bioactive compounds may be due to their capability to normalize impaired membrane function.
“The hepatoprotective and antioxidant potential of bioactive compounds may be due to their capability to normalize impaired membrane function (De Oliveira e Silva et al., 2012).”
From Hepatoprotective effects of bioactive compounds from traditional herb Tulsi (Ocimum sanctum Linn) against galactosamine-induced hepatotoxicity in rats (2023) · cites this paper as De Oliveira e Silva et al., 2012
The Conclusion (page not available) reports that Halimeda opuntia phenolic fractions attenuated liver damage in rats and showed antioxidant capacity. It does not attribute those effects to normalization of impaired membrane function; instead, the Abstract (page not available) suggests modulation of antioxidant enzymes and oxidative status. (LLM, conf=0.86)
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References 44 · Cited by 34
Research works printed but not linked: 6
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- Authors
- de Oliveira e Silva, A. M., Vidal-Novoa, A., Batista-González, A. E., Pinto, J. R., Portari Mancini, D. A., Reina-Urquijo, W., & Mancini-Filho, J.
- Affiliations
- University of Havana (CU)
- Instituto Butantan (BR)
- Universidade de São Paulo (BR)
- Venue
- Redox Report
- Publisher
- Informa UK Limited
- Published
- 2012-03
- Volume
- 17
- Issue
- 2
- Pages
- 47-53
- ISSN
- 1351-0002 (ISSN-L)
- 1743-2928
- PMC
- PMC6837672
- OpenAlex
- W2029210184
- Cited by
- 34
- References
- 44
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 1
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Redox Report (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade de São Paulo
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- Halimeda opuntia, polyphenols, antioxidant activity, hepatoprotection, carbon tetrachloride-induced liver injury, oxidative stress, superoxide dismutase, catalase, phenolic acids, lipid peroxidation, seaweed extract
- MeSH terms
- Chlorophyta, Animals, Antioxidants, Carbon Tetrachloride Poisoning, Catalase, Liver, Male, Superoxide Dismutase, Rats, Wistar, Rats, Chemical and Drug Induced Liver Injury, Polyphenols
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