The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Autologous stem cell transplantation followed by a dose-reduced allograft induces high complete remission rate in multiple myeloma
Abstract
We evaluated toxicity, engraftment, chimerism, graft-versus-host disease (GVHD), and response to a dose-reduced allograft after cytoreductive autografting in 17 patients with advanced stage II/III multiple myeloma (MM). After autografting with melphalan (200 mg/m2) the patients received after a median interval of 119 days (range 60-210) a dose-reduced regimen consisting of fludarabine (180 mg/m2), melphalan (100 mg/m2), and antithymocyte globulin (3 × 10 mg/kg) followed by allografting from related (n = 7), mismatched related (n = 2), or unrelated (n = 8) donors to induce a graft-versus-myeloma effect. After dose-reduced allografting all patients became neutropenic (< 0.2 × 109/L) for at least 8 days. All patients engrafted with a median time for leukocyte (> 1 × 109/L) and platelet (> 20 × 109/L) counts of 16 (range, 11-24) and 23 days (range, 12-43), respectively. Complete donor chimerism was detected after a median of 30 days (range, 19-38). Acute GVHD stage II occurred in 4 patients (25%) and grade III GVHD in 2 patients (13%). Chronic GVHD developed in 40% of the patients, but only 1 patient experienced extensive chronic GVHD requiring further immunosuppressive therapy. Two patients died of alveolar hemorrhage and pneumonia, resulting in a day 100 mortality rate of 11%. The rate of complete remission with negative immunofixation increased from 18% after autografting to 73% after allografting. After a median follow-up of 17 months after autologous and 13 months after allogeneic transplantation 13 patients are alive and 12 of them free of relapse or progression. The tandem auto-allotransplant protocol is highly active and provides rapid engraftment with complete donor chimerism and tolerable toxicity.
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Cited by
A Comparison of Allografting with Autografting for Newly Diagnosed Myeloma
Bruno, B., Rotta, M., Patriarca, F., Mordini, N., Allione, B., Carnevale-Schianca, F., Giaccone, L., Sorasio, R., Omedè, P., Baldi, I., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065464 · Cited by 501
Molecular mechanisms of novel therapeutic approaches for multiple myeloma
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Rosiñol, L., Pérez-Simón, J. A., Sureda, A., de la Rubia, J., de Arriba, F., Lahuerta, J. J., González, J. D., Díaz-Mediavilla, J., Hernández, B., García-Frade, J., et al. (2008) · Blood · doi:10.1182/blood-2008-02-141598 · Cited by 264
Metadata
- Authors
- Kröger, N., Schwerdtfeger, R., Kiehl, M., Sayer, H. G., Renges, H., Zabelina, T., Fehse, B., Tögel, F., Wittkowsky, G., Kuse, R., & Zander, A. R.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2002-08-01
- Volume
- 100
- Issue
- 3
- Pages
- 755-760
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2121236166
- Cited by
- 255
- References
- 17
- FWCI
- 11.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kröger, N., Schwerdtfeger, R., Kiehl, M., Sayer, H. G., Renges, H., Zabelina, T., Fehse, B., Tögel, F., Wittkowsky, G., Kuse, R., & Zander, A. R. (2002). Autologous stem cell transplantation followed by a dose-reduced allograft induces high complete remission rate in multiple myeloma. Blood. https://doi.org/10.1182/blood-2002-01-0131
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