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CD11c gene expression in hairy cell leukemia is dependent upon activation of the proto-oncogenes ras andjunD

Nicolaou, Fotini, Teodoridis, Jens M., Park, Heiyoung, Georgakis, Alexander, Farokhzad, Omid C., Böttinger, Erwin P., Da Silva, Nicolas, Rousselot, Philippe, Chomienne, Christine, Ferenczi, Katalin, Arnaout, M. Amin, Shelley, C. Simon·2003·Blood
DOI 10.1182/blood-2002-01-0324
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Abstract

Hairy cell leukemia (HCL) is a chronic lymphoproliferative disease, the cause of which is unknown. Diagnostic of HCL is abnormal expression of the gene that encodes the β2 integrin CD11c. In order to determine the cause of CD11c gene expression in HCL theCD11c gene promoter was characterized. Transfection of theCD11c promoter linked to a luciferase reporter gene indicated that it is sufficient to direct expression in hairy cells. Mutation analysis demonstrated that of predominant importance to the activity of the CD11c promoter is its interaction with the activator protein-1 (AP-1) family of transcription factors. Comparison of nuclear extracts prepared from hairy cells with those prepared from other cell types indicated that hairy cells exhibit abnormal constitutive expression of an AP-1 complex containing JunD. Functional inhibition of AP-1 expressed by hairy cells reducedCD11c promoter activity by 80%. Inhibition of Ras, which represents an upstream activator of AP-1, also significantly inhibited the CD11c promoter. Furthermore, in the hairy cell line EH, inhibition of Ras signaling through mitogen-activated protein kinase/extracellular signal–regulated kinase kinases 1 and 2 (MEK1/2) reduced not only CD11c promoter activity but also reduced both CD11c surface expression and proliferation. Expression in nonhairy cells of a dominant-positive Ras mutant activated the CD11cpromoter to levels equivalent to those in hairy cells. Together, these data indicate that the abnormal expression of the CD11cgene characteristic of HCL is dependent upon activation of the proto-oncogenes ras and junD.

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Research works printed but not linked: 105

  1. Bouroncle, 1958, Leukemic reticuloendotheliosis., Blood., 13, 609, 10.1182/blood.V13.7.609.609 · DOI
  2. Schwarting, 1985, The monoclonal antibodies αS-HCL1 (αLeu-14) and αS-HCL3 (αLeu-M5) allow the diagnosis of hairy cell leukemia., Blood., 65, 974, 10.1182/blood.V65.4.974.bloodjournal654974 · DOI
  3. Golde, 1977, Immunoglobulin synthesis in hairy cell leukemia., Brit J Haematol., 35, 359, 10.1111/j.1365-2141.1977.tb00595.x · DOI
  4. Saxon, 1978, T-lymphocyte varient of hairy-cell leukemia., Ann Int Med., 88, 323, 10.7326/0003-4819-88-3-323 · DOI
  5. Arnaout, 1990, Structure and function of the leukocyte adhesion molecules CD11/CD18., Blood., 75, 1037, 10.1182/blood.V75.5.1037.1037 · DOI
  6. Ogura, 1985, Establishment of a novel human megakaryoblastic leukemia cell line, MEG-01, with positive Philadelphia chromosome., Blood., 66, 1384, 10.1182/blood.V66.6.1384.1384 · DOI
  7. Faguet, 1988, Cytochemical, cytogenetic, immunophenotypic and tumorigenic characterization of two hairy cell lines., Blood., 71, 422, 10.1182/blood.V71.2.422.422 · DOI
  8. Shelley, 1993, Identification of cell-specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CD11a gene., Proc Natl Acad Sci U S A., 90, 5364, 10.1073/pnas.90.11.5364 · DOI
  9. López-Cabrera, 1993, Characterization of the p150,95 leukocyte integrin α subunit (CD11c) gene promoter., J Biol Chem., 268, 1187, 10.1016/S0021-9258(18)54058-8 · DOI
  10. Potter, 1984, Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation., Proc Natl Acad Sci U S A., 81, 7161, 10.1073/pnas.81.22.7161 · DOI
  11. Shelley, 1991, The promoter of the CD11b gene directs myeloid-specific and developmentally regulated expression., Proc Natl Acad Sci U S A., 88, 10525, 10.1073/pnas.88.23.10525 · DOI
  12. Farokhzad, 1996, Induction of the CD11b gene during activation of the monocytic cell line U937 requires a novel nuclear factor MS-2., J Immunol., 157, 5597, 10.4049/jimmunol.157.12.5597 · DOI
  13. Saxon, 1978, T-lymphocyte varient of hairy-cell leukemia., Ann Intern Med., 88, 323, 10.7326/0003-4819-88-3-323 · DOI
  14. Saxon, 1978, Immunologic characterization of hairy cell leukemias in continuous culture., J Immunol., 120, 777, 10.4049/jimmunol.120.3.777 · DOI
  15. Noti, 1996, Sp1 binds two sites in the CD11c promoter in vivo specifically in myeloid cells and cooperates with AP1 to activate transcription., Mol Cell Biol., 16, 2940, 10.1128/MCB.16.6.2940 · DOI
  16. López-Rodrı́guez, 1995, Identification of Sp1-binding sites in the CD11c (p150,95α) and CD11a (LFA-1α) integrin subunit promoters and their involvement in the tissue-specific expression of CD11c., Eur J Immunol., 25, 3496, 10.1002/eji.1830251243 · DOI
  17. Noti, 1997, Sp3 mediates transcriptional activation of the leukocyte integrin genes CD11C and CD11B and cooperates with c-Jun to activate CD11C., J Biol Chem., 272, 24038, 10.1074/jbc.272.38.24038 · DOI · Paper page
  18. Farokhzad, 2000, CD43 gene expression is mediated by a nuclear factor which binds pyrimidine-rich single-stranded DNA., Nucleic Acids Res., 28, 2256, 10.1093/nar/28.11.2256 · DOI
  19. Shelley, 2002, During differentiation of the monocytic cell line U937, Purα mediates induction of the CD11c β2 integrin gene promoter., J Immunol., 168, 3887, 10.4049/jimmunol.168.8.3887 · DOI
  20. Rubio, 1995, Granulocyte-macrophage colony-stimulating factor, phorbol ester, and sodium butyrate induce the CD11c integrin gene promoter activity during myeloid cell differentiation., Blood., 86, 3715, 10.1182/blood.V86.10.3715.bloodjournal86103715 · DOI
  21. Lassar, 1989, MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer., Cell., 58, 823, 10.1016/0092-8674(89)90935-5 · DOI
  22. López-Rodrı́guez, 1996, AP-1 regulates the basal and developmentally induced transcription of the CD11c leukocyte integrin gene., J Immunol., 156, 3780, 10.4049/jimmunol.156.10.3780 · DOI
  23. Aragonés, 1996, Dithiocarbamates trigger differentiation and induction of CD11c gene through AP-1 in the myeloid lineage., J Biol Chem., 271, 10924, 10.1074/jbc.271.18.10924 · DOI
  24. Noti, 1996, Regulation of the leukocyte integrin gene CD11c is mediated by AP1 and Ets transcription factors., Mol Immunol., 33, 115, 10.1016/0161-5890(95)00140-9 · DOI
  25. Vivanco Ruiz Md, 1991, Functional characterization of a natural retinoic acid responsive element., EMBO J., 10, 3829, 10.1002/j.1460-2075.1991.tb04952.x · DOI
  26. Corbı́, 1997, CD11c integrin gene promoter activity during myeloid differentiation., Leuk Lymphoma., 25, 415, 10.3109/10428199709039028 · DOI
  27. López-Rodrı́guez, 1997, PU.1 negatively regulates the CD11c integrin gene promoter through recognition of the major transcriptional start site., Eur J Immunol., 27, 1843, 10.1002/eji.1830270804 · DOI
  28. Smale, 1989, The initiator as a transcriptional control element., Cell., 57, 103, 10.1016/0092-8674(89)90176-1 · DOI
  29. Weis, 1992, Transcription by RNA polymerase II: initiator-directed formation of transcription-competent complexes., FASEB J., 6, 3300, 10.1096/fasebj.6.14.1426767 · DOI
  30. Akira, 1990, A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family., EMBO J., 9, 1897, 10.1002/j.1460-2075.1990.tb08316.x · DOI
  31. Pearse, 1993, Interferon γ-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3., Proc Natl Acad Sci U S A., 90, 4314, 10.1073/pnas.90.9.4314 · DOI
  32. Graf, 1992, Myb: a transcriptional activator linking proliferation and differentiation., Curr Opin Genet Dev., 2, 249, 10.1016/S0959-437X(05)80281-3 · DOI
  33. Brown, 1993, Suppression of oncogene-induced transformation by a deletion mutant of c-jun., Oncogene., 8, 877
  34. Feig, 1988, Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP., Mol Cell Biol., 8, 3235, 10.1128/MCB.8.8.3235 · DOI
  35. Berger, 1994, The human junD gene is positively and selectively autoregulated., DNA Cell Biol., 13, 249, 10.1089/dna.1994.13.249 · DOI
  36. Sweet, 1984, The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity., Nature., 311, 273, 10.1038/311273a0 · DOI
  37. Karin, 1997, AP-1 function and regulation., Curr Opin Cell Biol., 9, 240, 10.1016/S0955-0674(97)80068-3 · DOI
  38. Shields, 2000, Understanding Ras: ‘it ain’t over ‘til it’s over.', Trends Cell Biol., 10, 147, 10.1016/S0962-8924(00)01740-2 · DOI
  39. Avruch, 2001, Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade., Recent Prog Horm Res., 56, 127, 10.1210/rp.56.1.127 · DOI
  40. Kerkhoff, 2001, The Ras-Raf relationship: an unfinished puzzle., Adv Enzyme Regul., 41, 261, 10.1016/S0065-2571(00)00023-6 · DOI
  41. Bar-Sagi, 2000, Ras and Rho GTPases: a family reunion., Cell., 103, 227, 10.1016/S0092-8674(00)00115-X · DOI
  42. Jun, 1999, Tangled webs: evidence of cross-talk between c-Raf-1 and Akt., Sci STKE., 1999, PE1, 10.1126/stke.1999.13.pe1 · DOI
  43. Feig, 1996, Evidence for a Ras/Ral signaling cascade., Trends Biochem Sci., 21, 438, 10.1016/S0968-0004(96)10058-X · DOI
  44. Wolthuis, 1999, Ras caught in another affair: the exchange factors for Ral., Curr Opin Genetic Dev., 9, 112, 10.1016/S0959-437X(99)80016-1 · DOI
  45. Favata, 1998, Identification of a novel inhibitor of mitogen-activated protein kinase kinase., J Biol Chem., 273, 18623, 10.1074/jbc.273.29.18623 · DOI
  46. Sundstrom, 1976, Establishment and characterization of a human histiocytic lymphoma cell line (U-937)., Int J Cancer., 17, 565, 10.1002/ijc.2910170504 · DOI
  47. Shaulian, 2001, AP-1 in cell proliferation and survival., Oncogene., 20, 2390, 10.1038/sj.onc.1204383 · DOI
  48. Heintz, 1993, Persistent induction of c-fos and c-jun expression by asbestos., Proc Natl Acad Sci U S A., 90, 3299, 10.1073/pnas.90.8.3299 · DOI · Paper page
  49. Yamanishi, 1991, Expression of c-jun, jun-B, and c-fos proto-oncogenes in human primary melanocytes and metastatic melanomas., J Invest Dermatol., 97, 349, 10.1111/1523-1747.ep12480698 · DOI
  50. Fujimoto, 1989, Proto-oncogene analysis in brain tumors., J Neurosurg., 70, 910, 10.3171/jns.1989.70.6.0910 · DOI
  51. Neyns, 1996, Expression of the jun family of genes in human ovarian cancer and normal ovarian surface epithelium., Oncogene., 12, 1247
  52. Miller, 1984, c-fos protein can induce cellular transformation: a novel mechanism of activation of a cellular oncogene., Cell., 36, 51, 10.1016/0092-8674(84)90073-4 · DOI
  53. Lee, 1988, Activation of the transforming potential of the human fos proto-oncogene requires message stabilization and results in increased amounts of partially modified fos protein., Mol Cell Biol., 8, 5521, 10.1128/MCB.8.12.5521 · DOI
  54. Raymond, 1989, Removal of an mRNA destabilizing element correlates with the increased oncogenicity of proto-oncogene fos., Oncogene Res., 5, 1
  55. Schütte, 1989, Deregulated expression of human c-jun transforms primary rat embryo cells in cooperation with an activated c-Ha-ras gene and transforms Rat-1a cells as a single gene., Proc Natl Acad Sci U S A., 86, 2257, 10.1073/pnas.86.7.2257 · DOI
  56. Schütte, 1989, jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun., Cell., 59, 987, 10.1016/0092-8674(89)90755-1 · DOI
  57. Boyle, 1991, Activation of protein kinase C decreases phosphorylation of c-jun at sites that negatively regulate its DNA-binding activity., Cell., 64, 573, 10.1016/0092-8674(91)90241-P · DOI
  58. Van Beveren, 1983, Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini., Cell., 32, 1241, 10.1016/0092-8674(83)90306-9 · DOI
  59. Van Beveren, 1984, FBR murine osteosarcoma virus, II: nucleotide sequence of the provirus reveals that the genome contains sequences acquired from two cellular genes., Virology., 135, 229, 10.1016/0042-6822(84)90133-8 · DOI
  60. Nishizawa, 1987, An avian transforming retrovirus isolated from a nephroblastoma that carries the fos gene as the oncogene., J Virol., 61, 3733, 10.1128/JVI.61.12.3733-3740.1987 · DOI
  61. Maki, 1987, Avian sarcoma virus 17 carries the jun oncogene., Proc Natl Acad Sci U S A., 84, 2848, 10.1073/pnas.84.9.2848 · DOI
  62. Forrest, 1992, Crossed signals: oncogenic transcription factors., Curr Opin Genet Dev., 2, 19, 10.1016/S0959-437X(05)80316-8 · DOI
  63. Curran, 1984, Viral and cellular fos proteins: a comparative analysis., Cell., 36, 259, 10.1016/0092-8674(84)90219-8 · DOI
  64. Curran, 1985, Viral and cellular fos proteins are complexed with a 39,000-dalton cellular protein., Mol Cell Biol., 5, 167, 10.1128/MCB.5.1.167 · DOI
  65. Kameda, 1993, JunD mutants with spontaneously acquired transforming potential have enhanced transactivating activity in combination with Fra-2., Proc Natl Acad Sci U S A., 90, 9369, 10.1073/pnas.90.20.9369 · DOI
  66. Qin, 1999, Constitutive and interleukin-7/interleukin-15 stimulated DNA binding of Myc, Jun, and novel Myc-like proteins in cutaneous T-cell lymphoma cells., Blood., 93, 260, 10.1182/blood.V93.1.260 · DOI
  67. Mori, 2000, Constitutive activation of transcription factor AP-1 in primary adult T-cell leukemia cells., Blood., 95, 3915
  68. Blayney, 1983, The human T-cell leukemia/lymphoma virus associated with American adult T-cell leukemia/lymphoma., Blood., 62, 401, 10.1182/blood.V62.2.401.bloodjournal622401 · DOI
  69. Naeim, 1979, Sézary syndrome: tartrate-resistant acid phosphatase in the neoplastic cells., Am J Clin Pathol., 71, 528, 10.1093/ajcp/71.5.528 · DOI
  70. Usui, 1982, Existence of tartrate-resistant acid phosphatase activity in differentiated lymphoid leukemic cells., Am J Hematol., 12, 47, 10.1002/ajh.2830120107 · DOI
  71. Gallo, 1984, Kaplan memorial lecture: the family of human lymphotropic retroviruses called HTLV:HTLV-I in adult T-cell leukemia (ATL), HTLV-II in hairy cell leukemias, and HTLV-III in AIDS., Princess Takamatsu Symp., 15, 13
  72. Wachsman, 1984, Hairy cell leukemia and human T cell leukemia virus., Semin Oncol., 11, 446
  73. Clore, 1999, Chronic urticaria as a presenting sign of hairy cell leukemia., Allergy Asthma Proc., 20, 51, 10.2500/108854199778681530 · DOI
  74. Crump, 1991, Sézary syndrome in a patient with hairy cell leukemia in remission., Cancer., 68, 829, 10.1002/1097-0142(19910815)68:4<829::AID-CNCR2820680427>3.0.CO;2-1 · DOI
  75. Zucker-Franklin, 1982, Evolution of Sézary syndrome in the course of hairy cell leukemia., Blood., 59, 1181, 10.1182/blood.V59.6.1181.bloodjournal5961181 · DOI
  76. Demeter, 1992, Observations on the development of T-cell leukaemia in the patient successfully treated by interferon-α for typical hairy cell leukaemia (HCL)., Leukemia., 6, 1235
  77. Knecht, 1991, Genotypic and phenotypic evidence of T-cell leukemia in a patient successfully treated by interferon-α for typical hairy cell leukemia., Leukemia., 5, 1031
  78. Paolini, 2000, Co-existence of cutaneous T-cell lymphoma and B hairy cell leukemia., Am J Hematol., 64, 197, 10.1002/1096-8652(200007)64:3<197::AID-AJH10>3.0.CO;2-F · DOI
  79. Dearden, 2000, Clinical overview of pentostatin (Nipent) use in lymphoid malignancies., Semin Oncol., 27, 22
  80. Ho, 2000, Pentostatin (Nipent) in T-cell malignancies: Leukemia Cooperative Group and the European Organization for Research and Treatment of Cancer., Semin Oncol., 27, 52
  81. Beutler, 1992, Cladribine (2-chlorodeoxyadenosine)., Lancet., 340, 952, 10.1016/0140-6736(92)92826-2 · DOI
  82. Piro, 1992, 2-Chlorodeoxyadenosine treatment of lymphoid malignancies., Blood., 79, 843, 10.1182/blood.V79.4.843.843 · DOI
  83. Piro, 1990, Lasting remissions in hairy-cell leukemia induced by a single infusion of 2-chlorodeoxyadenosine., N Engl J Med., 322, 1117, 10.1056/NEJM199004193221605 · DOI
  84. Angel, 1987, Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor., Cell., 49, 729, 10.1016/0092-8674(87)90611-8 · DOI
  85. Lamph, 1988, Induction of proto-oncogene JUN/Ap-1 by serum and TPA., Nature., 334, 629, 10.1038/334629a0 · DOI
  86. Wilson, 1988, Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences., Nature., 336, 396, 10.1038/336396a0 · DOI
  87. Nakamura, 1991, Regulation of jun and fos gene expression in human monocytes by the macrophage colony-stimulating factor., Cell Growth Differ., 2, 267
  88. Abate, 1990, A ubiquitous nuclear protein stimulates the DNA-binding activity of fos and jun indirectly., Cell Growth Differ., 1, 455
  89. Abate, 1990, Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: both Fos and Jun contact DNA directly., Proc Natl Acad Sci U S A., 87, 1032, 10.1073/pnas.87.3.1032 · DOI
  90. Xanthoudakis, 1992, Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity., EMBO J., 11, 653, 10.1002/j.1460-2075.1992.tb05097.x · DOI · Paper page
  91. Curran, 1985, Superinduction of c-fos by nerve growth factor in the presence of peripherally active benzodiazepines., Science., 229, 1265, 10.1126/science.4035354 · DOI
  92. Barber, 1987, Modification of fos proteins: phosphorylation of c-fos, but not v-fos, is stimulated by 12-tetradecanoyl-phorbol-13- acetate and serum., Mol Cell Biol., 7, 2201, 10.1128/MCB.7.6.2201 · DOI
  93. Müller, 1987, Different types of modification in c-fos and its associated protein p39: modulation of DNA binding by phosphoylation., Oncogene Res., 2, 19
  94. Franza, 1988, The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites., Science., 239, 1150, 10.1126/science.2964084 · DOI
  95. Pulverer, 1991, Phosphorylation of c- jun mediated by MAP kinases., Nature., 353, 670, 10.1038/353670a0 · DOI
  96. Franklin, 1992, Phorbol ester-induced amino-terminal phosphorylation of human JUN but not JUNB regulates transcriptional activation., Proc Natl Acad Sci U S A., 89, 7247, 10.1073/pnas.89.15.7247 · DOI
  97. Minden, 1994, Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK., Science., 266, 1719, 10.1126/science.7992057 · DOI
  98. Coso, 1995, The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway., Cell., 81, 1137, 10.1016/S0092-8674(05)80018-2 · DOI · Paper page
  99. Minden, 1995, Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs., Cell., 81, 1147, 10.1016/S0092-8674(05)80019-4 · DOI
  100. Hart, 1994, Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product., J Biol Chem., 269, 62, 10.1016/S0021-9258(17)42313-1 · DOI
  101. Horii, 1994, A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways., EMBO J., 13, 4776, 10.1002/j.1460-2075.1994.tb06803.x · DOI
  102. Ridley, 1992, The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors., Cell., 70, 389, 10.1016/0092-8674(92)90163-7 · DOI
  103. Ridley, 1992, The small GTP-binding protein rac regulates growth factor-induced membrane ruffling., Cell., 70, 401, 10.1016/0092-8674(92)90164-8 · DOI
  104. Vandel, 1996, Stepwise transformation of rat embryo fibroblasts: c-Jun, JunB, or JunD can cooperate with Ras for focus formation, but a c-Jun-containing heterodimer is required for immortalization., Mol Cell Biol., 16, 1881, 10.1128/MCB.16.5.1881 · DOI
  105. Harvey, 1994, Interferon-alpha-2b downregulation of oncogenes H-ras, c-raf-2, c-kit, c-myc, c-myb and c-fos in ESKOL, a hairy cell leukemic line, results in temporal perturbation of signal transduction cascade., Leuk Res., 18, 577, 10.1016/0145-2126(94)90039-6 · DOI

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Metadata

Authors
Nicolaou, F., Teodoridis, J. M., Park, H., Georgakis, A., Farokhzad, O. C., Böttinger, E. P., Da Silva, N., Rousselot, P., Chomienne, C., Ferenczi, K., Arnaout, M. A., & Shelley, C. S.
Affiliations
From the Renal Unit, Massachusetts General Hospital, Charlestown, MA; the Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA; the Division of Nephrology, Albert Einstein College of Medicine, Bronx, NY; Institut de Hematologié, Hôpital Saint-Louis, Paris, France; and the Department of Dermatology, Brigham and Women's Hospital, Boston, MA.
Venue
Blood
Publisher
American Society of Hematology
Published
2003-05-15
Volume
101
Issue
10
Pages
4033-4041
ISSN
  • 1528-0020
  • 0006-4971
DOI
10.1182/blood-2002-01-0324
Cited by
39
References
4
Language
en

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