Current molecular models for NADPH oxidase regulation by Rac GTPase
Abstract
Reactive oxygen species (ROS) have been increasingly recognized as important components of cell signaling in addition to their well-established roles in host defense. The formation of ROS in phagocytic and nonphagocytic cells involves membrane-localized and Rac guanosine triphosphatase (GTPase)–regulated reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase(s). We discuss here the current molecular models for Rac GTPase action in the control of the phagocytic leukocyte NADPH oxidase. As a mechanistically detailed example of Rac GTPase signaling, the NADPH oxidase provides a potential paradigm for signaling by Rho family GTPases in general.
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NOX1 activation requires p22phox, NOX-organizer 1 (NOXO1), NOX-activator 1 (NOXA1), and the GTPase Rac1.
“NOX1 activation requires p22phox, NOX-organizer 1 (NOXO1), NOX-activator 1 (NOXA1), and the GTPase Rac1 (24, 108, 348).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [108]
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References 48 · Cited by 336
- Authors
- Bokoch, G. M., & Diebold, B. A.
- Affiliations
- Scripps Research Institute (US)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2002-10-15
- Volume
- 100
- Issue
- 8
- Pages
- 2692-2695
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1972641293
- Cited by
- 336
- References
- 48
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 5 · 2022: 6 · 2021: 8 · 2020: 8 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 14 · 2013: 15 · 2012: 15
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- NADPH oxidase, Rac GTPase, reactive oxygen species, Rho GTPases, leukocyte signaling, phagocytes, oxidative stress signaling
- MeSH terms
- Animals, Homeostasis, Humans, Models, Molecular, Phagocytes, NADPH Oxidases, rac GTP-Binding Proteins
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