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Cited by 579

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Adult Burkitt leukemia and lymphoma

Open access
Blum, Kristie A., Lozanski, Gerard, Byrd, John C.·2004·Blood

Abstract

The World Health Organization Classification of Lymphoid Neoplasms identifies Burkitt lymphoma/leukemia as a highly aggressive mature B-cell neoplasm consisting of endemic, sporadic, and immunodeficiency-associated variants. These subtypes share many morphologic and immunophenotypic features, but differences exist in their clinical and geographic presentations. All of these subtypes possess chromosomal rearrangements of the c-myc oncogene, the genetic hallmark of Burkitt lymphoma that contributes to lymphomagenesis through alterations in cell cycle regulation, cellular differentiation, apoptosis, cellular adhesion, and metabolism. Brief-duration, high-intensity chemotherapy regimens containing aggressive central nervous system prophylaxis have had remarkable success in the treatment of this disease, with complete remission rates of 75% to 90% and overall survivals reaching 50% to 70% in adults. Although Burkitt lymphoma cells are extremely chemosensitive, biologically targeted therapies should be developed because current treatment options are suboptimal for patients with poor prognostic features or in the setting of relapsed disease.

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Crossref · 10.1182/blood-2004-02-0405

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Metadata

Authors
Blum, K. A., Lozanski, G., & Byrd, J. C.
Venue
Blood
Published
2004-11-15
Volume
104
Issue
10
Pages
3009-3020
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W2043843485
Cited by
579
References
47
FWCI
16.27
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Adult Burkitt leukemia and lymphoma. https://app.cochat.ai/papers/10.1182/blood-2004-02-0405
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Blum, K. A., Lozanski, G., & Byrd, J. C. (2004). Adult Burkitt leukemia and lymphoma. Blood. https://doi.org/10.1182/blood-2004-02-0405

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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