The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.
Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels
Open accessAbstract
ABCG2/BCRP is a member of the adenosine triphosphate–binding cassette (ABC) transporter family and is expressed in intestine, kidney, and liver, where it modulates the absorption and excretion of xenobiotic compounds. ABCG2 is also expressed in hematopoietic stem cells and erythroid cells; however, little is known regarding its role in hematopoiesis. Abcg2 null mice have increased levels of protoporphyrin IX (PPIX) in erythroid cells, yet the mechanism for this remains uncertain. We have found that Abcg2 mRNA expression was up-regulated in differentiating erythroid cells, coinciding with increased expression of other erythroid-specific genes. This expression pattern was associated with significant amounts of ABCG2 protein on the membrane of mature peripheral blood erythrocytes. Erythroid cells engineered to express ABCG2 had significantly lower intracellular levels of PPIX, suggesting the modulation of PPIX level by ABCG2. This modulating activity was abrogated by treatment with a specific ABCG2 inhibitor, Ko143, implying that PPIX may be a direct substrate for the transporter. Taken together, our results demonstrate that ABCG2 plays a role in regulating PPIX levels during erythroid differentiation and suggest a potential role for ABCG2 as a genetic determinant in erythropoietic protoporphyria.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A subsequent study determined the effects of ABCG2 overexpression and transporter inhibition on intracellular and extracellular PpIX, providing compelling evidence that PpIX is an ABCG2 substrate [119].”
From 5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy (2023) · cites this paper as [119]
Citations
Cites
Photodynamic therapy for cancer
Dolmans, D. E. J. G. J., Fukumura, D., & Jain, R. K. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1071 · Cited by 6,850
Thiebaut, F., Tsuruo, T., Hamada, H., Gottesman, M., Pastan, I., & Willingham, M. (1987) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.84.21.7735 · Cited by 2,823
A multidrug resistance transporter from human MCF-7 breast cancer cells
Doyle, L. A., Yang, W., Abruzzo, L. V., Krogmann, T. A., Gao, Y., Rishi, A. K., & Ross, D. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15665 · Cited by 2,372
Zhou, S., Schuetz, J. D., Bunting, K. D., Colapietro, A.-M., Sampath, J., Morris, J. J., Lagutina, I., Grosveld, G. C., Osawa, M., Nakauchi, H., et al. (2001) · Nature Medicine · doi:10.1038/nm0901-1028 · Cited by 2,280
Self-citationThe Human ATP-Binding Cassette (ABC) Transporter SuperfamilyPreprint
Dean, M. C., Rzhetsky, A., & Allikmets, R. L. (2001) · Genome Research · doi:10.1101/gr.184901 · Cited by 1,820
Maliepaard, M., Scheffer, G. L., Faneyte, I. F., van Gastelen, M. A., Pijnenborg, A. C. L. M., Schinkel, A. H., van de Vijver, M. J., Scheper, R. J., & Schellens, J. H. M. (2001) · PubMed · Cited by 1,130
The Human ATP-Binding Cassette (ABC) Transporter SuperfamilyPreprint
Dean, M. C. (2001) · Genome Research · doi:10.1101/gr.gr-1649r · Cited by 1,121
Goodell, M. A., Rosenzweig, M., Kim, H. L., Marks, D. F., DeMaria, M., Paradis, G. A., Grupp, S. A., Sieff, C. A., Mulligan, R. C., & Johnson, R. P. (1997) · Nature Medicine · doi:10.1038/nm1297-1337 · Cited by 1,086
Jonker, J. W., Buitelaar, M., Wagenaar, E., van der Valk, M. A., Scheffer, G. L., Scheper, R. J., Plösch, T., Kuipers, F., Elferink, R. P. J. O., Rosing, H., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202607599 · Cited by 822
Scharenberg, C. W., Harkey, M. A., & Torok‐Storb, B. (2002) · Blood · doi:10.1182/blood.v99.2.507 · Cited by 770
Cited by
Sorted by citations
Items 101–168 of 168
Lyoumi, S., Schmitt, C., Touitou, Y., Puy, H., & Djeridane, Y. (2008) · Chronobiology International · doi:10.1080/07420520802548242 · Cited by 12
Samant, M. D., Jackson, C. M., Felix, C. L., Jones, A., Goodrich, D. W., Foster, B. A., & Huss, W. J. (2015) · Stem Cells and Development · doi:10.1089/scd.2014.0293 · Cited by 12
Howley, R., Olsen, J., & Chen, B. (2024) · Photochemistry and Photobiology · doi:10.1111/php.13936 · Cited by 11
Phillips, J. D., Farrell, C., Wang, Y., Singal, A. K., Anderson, K. E., Balwani, M., Bissell, M., Bonkovsky, H. L., Seay, T., Paw, B. H., et al. (2018) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2018.10.005 · Cited by 10
Yamamoto, K., Suzu, S., Yoshidomi, Y., Hiyoshi, M., Harada, H., & Okada, S. (2007) · Immunology Letters · doi:10.1016/j.imlet.2007.08.008 · Cited by 10
Erythrocyte Protoporphyrin Fluorescence as a Potential Marker of Diabetes
Fauaz, G., Miranda, A. R., Gomes, C. Z., Courrol, L. C., Silva, F. R. D. O., Rocha, F. G. D. G., Schor, N., & Bellini, M. H. (2010) · Applied Spectroscopy · doi:10.1366/000370210791114248 · Cited by 10
Kawamura, S., Kato, T., & Fantel, A. G. (2014) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.21133 · Cited by 10
Śmiga, M., Ślęzak, P., Tracz, M., Cierpisz, P., Wagner, M. M., & Olczak, T. (2024) · Scientific Reports · doi:10.1038/s41598-024-82326-6 · Cited by 9
Watanabe, T., Nishio, Y., Yamamoto, Y., Shimizu, T., Li, X., Okita, H., & Kuroda, T. (2022) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2022.02.028 · Cited by 9
The genetic architecture of complete blood counts in lactating Holstein dairy cows
Siberski, C. J., Mayes, M. S., Gorden, P. J., Kramer, L., Bhatia, V., & Koltes, J. E. (2024) · Frontiers in Genetics · doi:10.3389/fgene.2024.1360295 · Cited by 8
Inhibition of ABCG2 prevents phototoxicity in a mouse model of erythropoietic protoporphyria
Zhu, J., Qin, F., Lei, S., Gu, R., Qi, Q., Lu, J. L., Anderson, K. E., Wipf, P., & Ma, X. (2024) · Nature Communications · doi:10.1038/s41467-024-54969-6 · Cited by 8
Tie, D., Fan, Z., Chen, D., Chen, X., Chen, Q., Chen, J., & Bo, H. (2022) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x22500471 · Cited by 8
Chou, D. B., Furlong, B. A., Posey, R. R., Kyprianou, C., O’Sullivan, L. R., David, R. M., Randle, S. J., Polanska, U. M., Travers, J., Urosevic, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33672-4 · Cited by 8
Howley, R., Mansi, M., Shinde, J., Restrepo, J., & Chen, B. (2023) · Photochemistry and Photobiology · doi:10.1111/php.13678 · Cited by 8
Expression of ABCG2 (BCRP) in mouse models with enhanced erythropoiesis
Latunde-Dada, G. O., Laftah, A. H., Masaratana, P., McKie, A. T., & Simpson, R. J. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00135 · Cited by 8
Yu, S., Qiao, X., Yang, Y., Gu, X., Sun, W., Liu, X., Zhang, D., Wang, L., & Song, L. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.11.029 · Cited by 7
Sakiyama, M., Matsuo, H., Toyoda, Y., Yonekura, Y., Ishikawa, T., Nakayama, A., Higashino, T., Kawamura, Y., Fujimoto, N., Shinomiya, N., et al. (2021) · Human Cell · doi:10.1007/s13577-021-00534-y · Cited by 7
The expression of BCRP/ABCG2 causes resistance to Photofrin®-PDT
Tsunoda, Y., Usuda, J., Imai, K., Kubota, M., Maehara, S., Ohtani, K., Inoue, T., Hirata, T., Ichinose, S., Ishizumi, T., et al. (2007) · Nippon Laser Igakkaishi · doi:10.2530/jslsm.28.355 · Cited by 6
The Expression and Function of ABC Transporters at the Blood-Brain Barrier
Zhang, W., Bamji‐Mirza, M., Chang, N., Haqqani, A. S., & Stanimirovic, D. B. (2015) · CRC Press eBooks · doi:10.1201/b18606-8 · Cited by 5
Boden, G. H., Scapa, E. F., Kanno, K., Cohen, D. E., Brosnan, M. E., Brosnan, J. T., Pessayre, D., Roy‐Chowdhury, N., Lu, Y., Roy‐Chowdhury, J., et al. (2007) · Wiley eBooks · doi:10.1002/9780470691861.ch2c · Cited by 5
Fu, Y., Lu, M., Liu, D. H., Wang, J., Zhang, H., Qi, G., & Wang, J. (2025) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-025-01292-9 · Cited by 4
OATP1B1/1B3 deficiency exacerbates hyperbilirubinemia in erythropoietic protoporphyria
Gu, R., Qin, F., Wang, L., Zhang, J., Emerson, J., Ma, Q., Lu, J. L., Anderson, K. E., Wang, J., & Ma, X. (2025) · Drug Metabolism and Disposition · doi:10.1016/j.dmd.2025.100105 · Cited by 3
Jungsuwadee, P., & Vore, M. E. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-046884-6.00426-7 · Cited by 3
N-Methyl Protoporphyrin IX: An Understudied Porphyrin
Xu, L., Qi, Q., Zhu, J., & Ma, X. (2022) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.2c00214 · Cited by 3
Ma, S., Liu, H., Sun, W., Mustafa, A., Xi, Y., Pu, F., Li, Y., Han, C., Bai, L., & He, H. (2020) · BMC Evolutionary Biology · doi:10.1186/s12862-020-01654-z · Cited by 3
Buks, R., Brusson, M., Cochet, S., Galochkina, T. V., Cassinat, B., Nemazanyy, I., Peyrard, T., Kiladjian, J., de Brevern, A. G., Azouzi, S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073530 · Cited by 3
Higuchi, T., Yamaguchi, F., Asakura, T., Yoshida, D., Oishi, Y., & Morita, A. (2020) · Journal of Nippon Medical School · doi:10.1272/jnms.jnms.2020_87-601 · Cited by 3
5-Aminolevulinic Acid: A Novel Approach to Improving Radioresistance in Prostate Cancer
Maesaka, F., Nakai, Y., Yoshida, T., Tomizawa, M., Shimizu, T., Owari, T., Onishi, K., Miyake, M., Kuniyasu, H., Fujimoto, K., et al. (2025) · Cancers · doi:10.3390/cancers17081286 · Cited by 2
Olsen, J., Chandratre, S., Alsalamah, L., Merenich, D., Myers, K. A., & Chen, B. (2025) · Photochemistry and Photobiology · doi:10.1111/php.70057 · Cited by 2
Exploiting porphyrin metabolism to inhibit angiogenesis
Giorgio, F. D., Mannino, G., Bonalume, V., Bibi, A., Martorana, C., Digiovanni, S., Riganti, C., Genova, T., Munaron, L., Ruhrberg, C., et al. (2026) · Angiogenesis · doi:10.1007/s10456-026-10034-y · Cited by 2
Yamashita, M., Tsukamoto, M., Imai, R., Muramatsu, H., & Nakagawa, H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157428 · Cited by 2
Chandratre, S., Olsen, J., & Chen, B. (2025) · Photochemistry and Photobiology · doi:10.1111/php.14077 · Cited by 1
Hu, B., Yu, H., Kong, L., Liu, S., & Li, Q. (2025) · Aquaculture · doi:10.1016/j.aquaculture.2025.743212 · Cited by 1
ABCG2 Genetic Variability in Drug Exposure and Toxicity: Implications for Clinical Practice
Božina, T., Šimičević, L., Ganoci, L., Lovrić, M., Domjanović, I. K., Trkulja, V., & Božina, N. (2026) · Toxics · doi:10.3390/toxics14040327 · Cited by 2
Dai, Y., Jiang, Y., Cao, C., Xu, Y., Lai, S., Zhu, W., Gao, M., Li, F., He, S., & Xu, J. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2406794122 · Cited by 1
Sorenson, M. D., Osipova, E., Spottiswoode, C. N., Jamie, G. A., Dixit, T., DaCosta, J., Sackton, T. B., Warren, W. C., & Balakrishnan, C. N. (2026) · Nature Ecology & Evolution · doi:10.1038/s41559-026-03216-w · Cited by 1
Rosen, M. B., Jeffay, S. C., Nichols, H. P., Hoopes, M. R., & Hunter, E. S. (2017) · Birth Defects Research · doi:10.1002/bdr2.1114 · Cited by 1
Lagas, J. S. (2009) · Utrecht University Repository (Utrecht University)
Identification of two new blood group systems, Langereis (LAN) and Junior (JR)
Arnaud, L. (2012) · ISBT Science Series · doi:10.1111/j.1751-2824.2012.01555.x
Heme biosynthesis: structure-activity studies of murine ferrochelatase
Shi, Z. (2006) · Digital Commons - University of South Florida (University of South Florida)
Genetic prognostic factors in acute myeloid leukemia
Erdei, A., Vellai, T., Andrikovics, H., & Váradi, A. (2014)
Regulation of ABCG2 Expression in the Lactating Mammary Gland
Wu, A. M. L. (2014) · TSpace (University of Toronto)
Jungsuwadee, P., & Vore, M. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.99186-4
Yang, J., Mao, Z., Wang, X., Zhuang, J., Gong, S., Gao, Z., Xu, G., Yang, N., & Sun, C. (2022) · Figshare · doi:10.6084/m9.figshare.21592819
Yang, J., Mao, Z., Wang, X., Zhuang, J., Gong, S., Gao, Z., Xu, G., Yang, N., & Sun, C. (2022) · Figshare · doi:10.6084/m9.figshare.21592807
Yang, J., Mao, Z., Wang, X., Zhuang, J., Gong, S., Gao, Z., Xu, G., Yang, N., & Sun, C. (2022) · Figshare · doi:10.6084/m9.figshare.21592801
Yang, J., Mao, Z., Wang, X., Zhuang, J., Gong, S., Gao, Z., Xu, G., Yang, N., & Sun, C. (2022) · Figshare · doi:10.6084/m9.figshare.21592804
Yang, J., Mao, Z., Wang, X., Zhuang, J., Gong, S., Gao, Z., Xu, G., Yang, N., & Sun, C. (2022) · Figshare · doi:10.6084/m9.figshare.21592789
Yang, J., Mao, Z., Wang, X., Zhuang, J., Gong, S., Gao, Z., Xu, G., Yang, N., & Sun, C. (2022) · Figshare · doi:10.6084/m9.figshare.21592792
Yang, J., Mao, Z., Wang, X., Zhuang, J., Gong, S., Gao, Z., Xu, G., Yang, N., & Sun, C. (2022) · Figshare · doi:10.6084/m9.figshare.21592816
Yang, J. H., Mao, Z., Wang, X., Zhuang, J., Gong, S., Gao, Z., Xu, G., Yang, N., & Sun, C. (2022) · Figshare · doi:10.6084/m9.figshare.21592813
Yang, J. H., Mao, Z., Wang, X., Zhuang, J., Gong, S., Gao, Z., Xu, G., Yang, N., & Sun, C. (2022) · Figshare · doi:10.6084/m9.figshare.21592795
Yang, J. H., Mao, Z., Wang, X., Zhuang, J., Gong, S., Gao, Z., Xu, G., Yang, N., & Sun, C. (2022) · Figshare · doi:10.6084/m9.figshare.21592810
Sato, S., Tsukamoto, M., Ozawa, K., Imai, R., & Nakagawa, H. (2025) · Research Square · doi:10.21203/rs.3.rs-6704269/v1
A Heterogeneous Graph Framework for Inference of Metabolite–Protein-Drug Interaction NetworksPreprint
Lu, Y., & C.Sriram, C. S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.18.695016
Lin, Z., Wu, R., Yang, Y., Ji, M., Liu, X., Liu, L., & Yang, H. (2026) · Drug Metabolism and Disposition · doi:10.1016/j.dmd.2026.100282
Role of nucleotide metabolite transporters in erythropoiesis and red blood cell functions
Mikdar, M. (2020) · theses.fr (ABES) · doi:10.70675/d5d836a7z9626z4a70z9038ze3b12cea9400
Role of hemopexin in protoporphyrin IX distribution and cholestatic liver injury
Gu, R., Qin, F., Sun, Z., Wang, X., Chen, E., Lu, J. L., Wang, J., & Ma, X. (2026) · Toxicological Sciences · doi:10.1093/toxsci/kfag041
Targeting the Heme biosynthesis pathway: strategies to enhance 5-ALA-mediated photodynamic therapy
Ren, J., Li, Y., Fu, J., Zhou, R., Zhang, C., & Xie, Y. (2026) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2026.130739
Shah, B., Huang, E. Y., Sinha, U., Hsieh, F., & Schmidt, P. (2026) · Analytical Biochemistry · doi:10.1016/j.ab.2026.116222
Effects of ABCG2 knockdown on therapeutic enhancement of 5‐aminolevulinic acid with lapatinib
Wescoat, J., Cabral, C., & Chen, B. (2026) · Photochemistry and Photobiology · doi:10.1111/php.70157
Sato, S., Tsukamoto, M., Ozawa, K., Ritsuko, I. M. A. I., & Nakagawa, H. (2026) · Biomolecules · doi:10.3390/biom16101486
BindingDB Entry 50022334: Metabolism-guided development of Ko143 analogs as ABCG2 inhibitors.
BindingDB (2025) · UC San Diego · doi:10.7270/q2kd23m3
Metadata
- Authors
- Zhou, S., Zong, Y., Ney, P. A., Nair, G., Stewart, C. F., & Sorrentino, B. P.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2005-03-15
- Volume
- 105
- Issue
- 6
- Pages
- 2571-2576
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC4757428
- OpenAlex
- W1977748061
- Cited by
- 157
- References
- 31
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 6 · 2023: 6 · 2022: 11 · 2021: 7 · 2020: 6 · 2019: 6 · 2018: 7 · 2017: 6 · 2016: 3 · 2015: 6 · 2014: 10 · 2013: 7 · 2012: 10
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL067366, R01-HL67366)
- National Cancer Institute (R01CA084214)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- ABCG2, ABC transporters, erythroid maturation, protoporphyrin IX, erythropoiesis, Ko143, erythropoietic protoporphyria, erythrocyte membrane, hematopoiesis, gene expression regulation
- MeSH terms
- ATP Binding Cassette Transporter, Subfamily G, Member 2, Animals, Biological Transport, Cell Differentiation, Enzyme Inhibitors, Erythrocyte Membrane, Erythropoiesis, Humans, Intestinal Mucosa, Kidney, Liver, Organ Specificity, Protoporphyrins, Mice, Knockout, ATP-Binding Cassette Transporters, K562 Cells, Protoporphyria, Erythropoietic, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
