The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Vessel wall–derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells
Abstract
Endothelial progenitor cells (EPCs) can be isolated from adult peripheral and umbilical cord blood and expanded exponentially ex vivo. In contrast, human umbilical vein endothelial cells (HUVECs) or human aortic endothelial cells (HAECs) derived from vessel walls are widely considered to be differentiated, mature endothelial cells (ECs). However, similar to adult- and cord blood–derived EPCs, HUVECs and HAECs derived from vessel walls can be passaged for at least 40 population doublings in vitro. Based on this paradox, we tested whether EPCs reside in HUVECs or HAECs utilizing a novel single cell deposition assay that discriminates EPCs based on their proliferative and clonogenic potential. We demonstrate that a complete hierarchy of EPCs can be identified in HUVECs and HAECs derived from vessel walls and discriminated by their clonogenic and proliferative potential. This study provides evidence that a diversity of EPCs exists in human vessels and provides a conceptual framework for determining both the origin and function of EPCs in maintaining vessel integrity.
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Cites
Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G., & Isner, J. M. (1997) · Science · doi:10.1126/science.275.5302.964 · Cited by 8,725
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091
Cited by
Assessing Identity, Phenotype, and Fate of Endothelial Progenitor Cells
Hirschi, K. K., Ingram, D. A., & Yoder, M. C. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.155960 · Cited by 746
Self-citationMacrophage Phenotype as a Determinant of Biologic Scaffold Remodeling
Badylak, S. F., Valentin, J. E., Ravindra, A. K., McCabe, G. P., & Stewart-Akers, A. M. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2007.0264 · Cited by 729
Vascular wall resident progenitor cells: a source for postnatal vasculogenesis
Zengin, E., Chalajour, F., Gehling, U. M., Ito, W. D., Treede, H., Lauke, H., Weil, J., Reichenspurner, H., Kilic, N., & Ergün, S. (2006) · Development · doi:10.1242/dev.02315 · Cited by 485
Vascular repair by endothelial progenitor cells
Zampetaki, A., Kirton, J. P., & Xu, Q. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn081 · Cited by 473
Endothelial Progenitors: A Consensus Statement on Nomenclature
Medina, R. J., Barber, C. L., Sabatier, F., Dignat-George, F., Melero-Martin, J. M., Khosrotehrani, K., Ohneda, O., Randi, A. M., Chan, J. K. Y., Yamaguchi, T., et al. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.16-0360 · Cited by 430
Metadata
- Authors
- Ingram, D. A., Mead, L. E., Moore, D. B., Woodard, W., Fenoglio, A., & Yoder, M. C.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2005-04-01
- Volume
- 105
- Issue
- 7
- Pages
- 2783-2786
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2087912166
- Cited by
- 582
- References
- 2
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ingram, D. A., Mead, L. E., Moore, D. B., Woodard, W., Fenoglio, A., & Yoder, M. C. (2005). Vessel wall–derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells. Blood. https://doi.org/10.1182/blood-2004-08-3057
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
