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Identification of novel vascular endothelial–specific genes by the microarray analysis of the zebrafish cloche mutants
Open accessAbstract
The zebrafish cloche (clo) mutation affects the earliest known step in differentiation of blood and endothelial cells in vertebrates. We established clo/gata1-GFP transgenic line with erythroid-specific green fluorescent protein (GFP) expression, which allowed differentiation of clo and wild-type siblings at the midsomitogenesis stages before morphologically visible phenotypes appeared. To discover novel genes potentially involved in hematopoietic and vascular development, we performed microarray analysis of more than 15 000 zebrafish genes or expressed sequence tags (ESTs) in clo mutant embryos. We isolated the full-length sequences and determined the expression patterns for 8 novel cDNAs that were significantly down-regulated in clo–/– embryos. Dual specificity phosphatase 5 (dusp5), cadherin 5 (cdh5; VE-cadherin), aquaporin 8 (aqp8), adrenomedullin receptor (admr), complement receptor C1qR-like (crl), scavenger receptor class F, member 1 (scarf1), and ETS1-like protein (etsrp) were specifically expressed in the vascular endothelial cells, while retinol binding protein 4 (rbp4) was expressed in the yolk syncytial layer and the hypochord. Further functional studies of these novel genes should help to elucidate critical early steps leading to the formation of vertebrate blood vessels.
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Cited by
Transcriptional Control of Endothelial Cell Development
De Val, S., & Black, B. L. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.014 · Cited by 346
“Expression of etsrp is restricted to vascular endothelial cells and their precursors, and knockdown of etsrp causes severe defects in vascular development, although with variable penetrance (Pham et al., 2007; Sumanas et al., 2005; Sumanas and Lin, 2006).”
BackgroundJagannathan-Bogdan, M., & Zon, L. I. (2013) · Development · doi:10.1242/dev.083147 · Cited by 346
Masiero, M., Simões, F. C., Han, H. D., Snell, C., Peterkin, T., Bridges, E., Mangala, L. S., Wu, S. Y.-Y., Pradeep, S., Li, D., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.06.004 · Cited by 313
Vegf signaling promotes vascular endothelial differentiation by modulating etv2 expression
Casie Chetty, S., Rost, M. S., Enriquez, J. R., Schumacher, J. A., Baltrunaite, K., Rossi, A., Stainier, D. Y. R., & Sumanas, S. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.03.005 · Cited by 76
Self-citationSchmid, C. D., Schledzewski, K., Mogler, C., Waldburger, N., Kalna, V., Marx, A., Randi, A. M., Géraud, C., Goerdt, S., & Koch, P.-S. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.01.185 · Cited by 33
Metadata
- Authors
- Sumanas, S., Jorniak, T., & Lin, S.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2005-07-15
- Volume
- 106
- Issue
- 2
- Pages
- 534-541
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2001784727
- Cited by
- 159
- References
- 0
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- green
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