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Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT
Open accessAbstract
We previously reported that the Charlson Comorbidity Index (CCI) was useful for predicting outcomes in patients undergoing allogeneic hematopoietic cell transplantation (HCT). However, the sample size of patients with scores of 1 or more, captured by the CCI, did not exceed 35%. Further, some comorbidities were rarely found among patients who underwent HCT. Therefore, the current study was designed to (1) better define previously identified comorbidities using pretransplant laboratory data, (2) investigate additional HCT-related comorbidities, and (3) establish comorbidity scores that were suited for HCT. Data were collected from 1055 patients, and then randomly divided into training and validation sets. Weights were assigned to individual comorbidities according to their prognostic significance in Cox proportional hazard models. The new index was then validated. The new index proved to be more sensitive than the CCI since it captured 62% of patients with scores more than 0 compared with 12%, respectively. Further, the new index showed better survival prediction than the CCI (likelihood ratio of 23.7 versus 7.1 and c statistics of 0.661 versus 0.561, respectively, P < .001). In conclusion, the new simple index provided valid and reliable scoring of pretransplant comorbidities that predicted nonrelapse mortality and survival. This index will be useful for clinical trials and patient counseling before HCT. (Blood. 2005;106: 2912-2919)
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“The hematopoietic-cell transplantation comorbidity index (HCT-CI) is a tool for assessing the risk of death after hematopoietic-cell transplantation.30”
From Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation (2020) · cites this paper as [30]
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Reduced Mortality after Allogeneic Hematopoietic-Cell Transplantation
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Self-citationValidation and refinement of the Disease Risk Index for allogeneic stem cell transplantation
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Metadata
- Authors
- Sorror, M. L., Maris, M. B., Storb, R., Baron, F., Sandmaier, B. M., Maloney, D. G., & Storer, B.
- Affiliations
- University of Washington (US)
- From the Fred Hutchinson Cancer Research Center, Seattle, WA; and the University of Washington, Seattle, WA.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2005-10-15
- Volume
- 106
- Issue
- 8
- Pages
- 2912-2919
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC1895304
- OpenAlex
- W2128812336
- Cited by
- 2,969
- References
- 62
- Citations by year
- 2026: 139 · 2025: 208 · 2024: 223 · 2023: 213 · 2022: 192 · 2021: 246 · 2020: 209 · 2019: 171 · 2018: 173 · 2017: 174 · 2016: 144 · 2015: 145 · 2014: 134 · 2013: 112 · 2012: 86
- FWCI
- 25.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ORBi (University of Liège) (submittedVersion, other-oa)
- Funders
- Fred Hutchinson Cancer Research Center
- University of Washington
- National Heart, Lung, and Blood Institute (HL-36444, P01HL036444)
- National Cancer Institute (CA 49605, CA18029, CA 15704+, K23CA092058, CA 78902, CA92058, P01CA049605, P30CA015704, P01CA018029, P01CA078902)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
- Keywords
- hematopoietic stem cell transplantation, allogeneic transplantation, comorbidity index, Charlson Comorbidity Index, risk assessment, non-relapse mortality, survival prediction, prognostic scoring
- MeSH terms
- Contraindications, Adolescent, Adult, Aged, Cause of Death, Child, Child, Preschool, Female, Humans, Infant, Male, Middle Aged, Prognosis, Transplantation, Homologous, Reproducibility of Results, Comorbidity, Survival Rate, Proportional Hazards Models, Treatment Outcome, Risk Assessment, Stem Cell Transplantation
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