The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Activating Notch1 mutations in mouse models of T-ALL
Open accessAbstract
Recent studies have demonstrated that most patients with T-cell acute lymphocytic leukemia (T-ALL) have activating mutations in NOTCH1. We sought to determine whether these mutations are also acquired in mouse models of T-ALL. We sequenced the heterodimerization domain and the PEST domain of Notch1 in our mouse model of TAL1-induced leukemia and found that 74% of the tumors harbor activating mutations in Notch1. Cell lines derived from these tumors undergo G0/G1 arrest and apoptosis when treated with a γ-secretase inhibitor. In addition, we found activating Notch1 mutations in 31% of thymic lymphomas that occur in mice deficient for various combinations of the H2AX, Tp53, and Rag2 genes. Thus, Notch1 mutations are often acquired as a part of the molecular pathogenesis of T-ALLs that develop in mice with known predisposing genetic alterations. (Blood. 2006;107:781-785)
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Cites
Genomic Instability in Mice Lacking Histone H2AX
Celeste, A., Petersen, S., Romanienko, P. J., Fernandez-Capetillo, O., Chen, H. T., Sedelnikova, O. A., Reina-San-Martin, B., Coppola, V., Meffre, E., Difilippantonio, M. J., et al. (2002) · Science · doi:10.1126/science.1069398 · Cited by 1,385
Cited by
Howe, S. J., Mansour, M. R., Schwarzwaelder, K., Bartholomae, C., Hubank, M., Kempski, H., Brugman, M. H., Pike-Overzet, K., Chatters, S. J., de Ridder, D., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35798 · Cited by 1,286
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
Weng, A. P., Millholland, J. M., Yashiro-Ohtani, Y., Arcangeli, M. L., Lau, A., Wai, C., del Bianco, C., Rodriguez, C. G., Sai, H., Tobias, J., et al. (2006) · Genes & Development · doi:10.1101/gad.1450406 · Cited by 870
Self-citationNotch Promotes Radioresistance of Glioma Stem Cells
Wang, J., Wakeman, T. P., Lathia, J. D., Hjelmeland, A. B., Wang, X.-F., White, R. R., Rich, J. N., & Sullenger, B. A. (2010) · Stem Cells · doi:10.1002/stem.261 · Cited by 656
Recent insights into the role of Notch signaling in tumorigenesis
Leong, K. G., & Karsan, A. (2006) · Blood · doi:10.1182/blood-2005-08-3329 · Cited by 493
Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia
Grabher, C., von Boehmer, H., & Look, A. T. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1880 · Cited by 425
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Metadata
- Authors
- O'Neil, J., Calvo, J., McKenna, K., Krishnamoorthy, V., Aster, J. C., Bassing, C. H., Alt, F. W., Kelliher, M., & Look, A. T.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2006-01-15
- Volume
- 107
- Issue
- 2
- Pages
- 781-785
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2113503593
- Cited by
- 233
- References
- 1
- FWCI
- 19.73
- Type
- journal article
- Language
- en
- Open access
- green
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- O'Neil, J., Calvo, J., McKenna, K., Krishnamoorthy, V., Aster, J. C., Bassing, C. H., Alt, F. W., Kelliher, M., & Look, A. T. (2006). Activating Notch1 mutations in mouse models of T-ALL. Blood. https://doi.org/10.1182/blood-2005-06-2553
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