Cited by 10

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More on Myb in myelofibrosis: molecular analyses of MYB and EP300 in 55 patients with myeloproliferative disorders

Steensma, David P., Pardanani, Animesh·2006·Blood

Abstract

RA) and cytogenetically characterized by deletion of the long arm of chromosome 20 (del(20q)), which was detected by fluorescence in situ hybridization (FISH) in 18% and 24.5% of unfractionated marrow and blood mononuclear cells, respectively.Nevertheless, donor cell engraftment was timely and the patient developed mild graft-versus-host disease that promptly responded to therapy.As of July 2005, the patient was alive, clinically well, and in complete remission of her lymphoma.The patient's hematopoietic function after transplantation has been remarkable for thrombocytopenia and mild normocytic anemia without evidence for progression (February 2005: hemoglobin level, 118 g/L [11.8 g/dL]; platelet count, 55 ϫ 10 9 /L; and absolute neutrophil count, 2.04 ϫ 10 9 /L).Current clinical information about the stem cell donor was not available.During the 7 years of posttransplantation follow-up, we analyzed donor cell engraftment in myeloid and lymphoid compartments of both blood and bone marrow using conventional cytogenetics, FISH, and variable number tandem repeats (VNTRs).Chimerism analysis by VNTRs confirmed 100% donor hematopoiesis in lymphoid and myeloid lineages by day 34 after transplantation, which has remained stable to date.Shortly after transplantation, at day 158, approximately 10% of granulocytes and monocytes in the blood carried the del(20q) abnormality; however, this population increased to represent 56% to 73% of blood myeloid cells by 3 and 7 years, respectively, a…

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Research works printed but not linked: 14

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Metadata

Authors
Steensma, D. P., & Pardanani, A.
Venue
Blood
Published
2006-02-15
Volume
107
Issue
4
Pages
1733-1735
ISSN
  • 0006-4971
  • 1528-0020
Cited by
10
References
2
Language
en

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Steensma, D. P., & Pardanani, A. (2006). More on Myb in myelofibrosis: molecular analyses of MYB and EP300 in 55 patients with myeloproliferative disorders. Blood. https://doi.org/10.1182/blood-2005-09-3646