The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Vascular endothelial cell–specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development
Abstract
VE-PTP, a receptor-type phosphotyrosine phosphatase, associates with the tyrosine kinase receptor Tie-2 and VE-cadherin and enhances the adhesive function of the latter. Here, VE-PTP was found to be restricted to endothelial cells, with a preference for arterial endothelium. Mutant mice expressing a truncated, secreted form of VE-PTP lacking the cytoplasmic and transmembrane domains and the most membrane-proximal extracellular fibronectin type III repeat, showed severe vascular malformations causing lethality at 10 days of gestation. Although blood vessels were initially formed, the intraembryonic vascular system soon deteriorated. Blood vessels in the yolk sac developed into dramatically enlarged cavities. In explant cultures of mutant allantoides, endothelial cells were found next to vessel structures growing as cell layers. No signs for enhanced endothelial apoptosis or proliferation were observed. Thus, the activity of VE-PTP is not required for the initial formation of blood vessels, yet it is essential for their maintenance and remodeling.
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The biology of VEGF and its receptors
Ferrara, N., Gerber, H.-P., & LeCouter, J. (2003) · Nature Medicine · doi:10.1038/nm0603-669 · Cited by 9,591
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X.-F., Breitman, M. L., & Schuh, A. C. (1995) · Nature · doi:10.1038/376062a0 · Cited by 3,931
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Mechanisms and regulation of endothelial VEGF receptor signalling
Simons, M., Gordon, E., & Claesson-Welsh, L. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.87 · Cited by 1,498
Vestweber (2008) · doi:10.1161/atvbaha.107.158014 · Cited by 806
Dejana, E., Tournier-Lasserve, E., & Weinstein, B. M. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.004 · Cited by 788
Brain barriers: Crosstalk between complex tight junctions and adherens junctions
Tietz, S., & Engelhardt, B. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201412147 · Cited by 551
The Role of VE-Cadherin in Vascular Morphogenesis and Permeability Control
Dejana, E., & Vestweber, D. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-394311-8.00006-6 · Cited by 203
Self-citation
Metadata
- Authors
- Bäumer, S., Keller, L., Holtmann, A., Funke, R., August, B., Gamp, A., Wolburg, H., Wolburg-Buchholz, K., Deutsch, U., & Vestweber, D.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2006-06-15
- Volume
- 107
- Issue
- 12
- Pages
- 4754-4762
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2030135968
- Cited by
- 158
- References
- 2
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Bäumer, S., Keller, L., Holtmann, A., Funke, R., August, B., Gamp, A., Wolburg, H., Wolburg-Buchholz, K., Deutsch, U., & Vestweber, D. (2006). Vascular endothelial cell–specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development. Blood. https://doi.org/10.1182/blood-2006-01-0141
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