Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen–specific CD8+ T-cell function in Hodgkin lymphoma patients

Gandhi, Maher K.; Lambley, Eleanore; Duraiswamy, Jaikumar; Dua, Ujjwal; Smith, Corey; Elliott, Suzanne; Gill, Devinder; Marlton, Paula; Seymour, John; Khanna, Rajiv

doi:10.1182/blood-2006-04-015164

Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen–specific CD8+ T-cell function in Hodgkin lymphoma patients

In Hodgkin lymphoma (HL), the malignant Hodgkin Reed-Sternberg (HRS) cells constitute only 0.5% of 10% of the diseased tissue. The surrounding cellular infiltrate is enriched with T cells that are hypothesized to modulate antitumor immunity. We show that a marker of regulatory T cells, LAG-3, is …