The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Correlation between antiphospholipid antibodies that recognize domain I of β2-glycoprotein I and a reduction in the anticoagulant activity of annexin A5
Abstract
The paradoxical correlation between thrombosis and the lupus anticoagulant (LAC) effect is an enigmatic feature of the antiphospholipid (aPL) syndrome. The Dutch authors previously reported that thrombosis-related anti–β2-glycoprotein I (β2GPI) antibodies recognize domain I and cause LAC. The American authors reported that aPLs disrupt an anticoagulant annexin A5 (AnxA5) crystal shield. We investigated whether antidomain I antibodies correlate with disruption of AnxA5-anticoagulant activity. We studied a well-characterized group of 33 patients including subgroups with β2GPI-dependent LAC that recognize domain I (n = 11), with β2GPI-independent LAC (n = 12), and lacking LAC (n = 10). The effects on AnxA5-anticoagulant activity were determined with an AnxA5 resistance assay that measures coagulation times with and without AnxA5. Patients with β2GPI-dependent LAC (group A, all with thrombosis) had significantly lower AnxA5-anticoagulant ratios than those with β2GPI-independent LAC (group B, thrombosis n = 4; 157.8% versus 235.6%, P < .001) and those without LAC (group C, thrombosis n = 2; 157.8% versus 232.5%, P < .001). There was no difference in the ratios between groups B and C (P = .92). Plasmas with β2GPI-dependent LAC that recognize domain I displayed significantly increased AnxA5 resistance, suggesting that specifically anti-β2GPI antibodies compete with AnxA5 for anionic phospholipids. These results are consistent with a model in which aPL antibodies may promote thrombosis by interfering with the anticoagulant activity of AnxA5.
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“Indeed, other antibodies against protein C/S and annexin V have also been shown to interfere with coagulation. 26,27”
From Clinical Relevance of Isolated Lupus Anticoagulant Positivity in Patients with Thrombotic Antiphospholipid Syndrome (2021) · cites this paper as [27]
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Metadata
- Authors
- de Laat, B., Wu, X.-X., van Lummel, M., Derksen, R. H. W. M., de Groot, P. G., & Rand, J. H.
- Affiliations
- University Medical Center Utrecht (NL)
- Albert Einstein College of Medicine (US)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2006-10-19
- Volume
- 109
- Issue
- 4
- Pages
- 1490-1494
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2047089135
- Cited by
- 122
- References
- 32
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 8 · 2019: 7 · 2018: 7 · 2017: 6 · 2016: 12 · 2015: 1 · 2014: 8 · 2013: 9 · 2012: 9
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Hematology › Heparin-Induced Thrombocytopenia and Thrombosis
- Keywords
- antiphospholipid syndrome, lupus anticoagulant, beta2-glycoprotein I, annexin V, anticoagulant activity, thrombosis, anionic phospholipids
- MeSH terms
- Adult, Epitopes, Binding Sites, Blood Coagulation, Female, Humans, Male, Thrombosis, Case-Control Studies, Lupus Coagulation Inhibitor, Antibodies, Antiphospholipid, Annexin A5, Thrombophilia, beta 2-Glycoprotein I
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