The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma
Abstract
There is no generally established prognostic index for patients with mantle cell lymphoma (MCL), because the International Prognostic Index (IPI) and Follicular Lymphoma International Prognostic Index (FLIPI) have been developed for diffuse large cell and follicular lymphoma patients, respectively. Using data of 455 advanced stage MCL patients treated within 3 clinical trials, we examined the prognostic relevance of IPI and FLIPI and derived a new prognostic index (MCL international prognostic index, MIPI) of overall survival (OS). Statistical methods included Kaplan-Meier estimates and the log-rank test for evaluating IPI and FLIPI and multiple Cox regression for developing the MIPI. IPI and FLIPI showed poor separation of survival curves. According to the MIPI, patients were classified into low risk (44% of patients, median OS not reached), intermediate risk (35%, 51 months), and high risk groups (21%, 29 months), based on the 4 independent prognostic factors: age, performance status, lactate dehydrogenase (LDH), and leukocyte count. Cell proliferation (Ki-67) was exploratively analyzed as an important biologic marker and showed strong additional prognostic relevance. The MIPI is the first prognostic index particularly suited for MCL patients and may serve as an important tool to facilitate risk-adapted treatment decisions in patients with advanced stage MCL.
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Weighted kappa: nominal scale agreement provision for scaled disagreement or partial credit
Cohen, J. (1968) · Psychological Bulletin · doi:10.1037/h0026256 · Cited by 8,736
Proportional hazards tests and diagnostics based on weighted residuals
GRAMBSCH, P. M., & THERNEAU, T. M. (1994) · Biometrika · doi:10.1093/biomet/81.3.515 · Cited by 5,885 · cited 1×
“Median platelet count, 109/L (range) 188 (3-1346) 452”
Partial residuals for the proportional hazards regression model
SCHOENFELD, D. (1982) · Biometrika · doi:10.1093/biomet/69.1.239 · Cited by 3,111
Dangers of Using "Optimal" Cutpoints in the Evaluation of Prognostic Factors
Altman, D. G., Lausen, B., Sauerbrei, W., & Schumacher, M. (1994) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/86.11.829 · Cited by 1,143
Cited by
Cheson, B. D., Fisher, R. I., Barrington, S. F., Cavalli, F., Schwartz, L. H., Zucca, E., & Lister, T. A. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.54.8800 · Cited by 5,715
KTE-X19 CAR T cell therapy in relapsed or refractory mantle-cell lymphoma
Wang, M., Munoz, J., Goy, A., Locke, F. L., Jacobson, C. A., Hill, B. T., Timmerman, J. M., Holmes, H., Jaglowski, S., Flinn, I. W., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1914347 · Cited by 1,862
Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma
Leonard, J. P., LaCasce, A. S., Smith, M. R., Noy, A., Chirieac, L. R., Rodig, S. J., Yu, J. Q., Vallabhajosula, S., Schoder, H., English, P., et al. (2012) · Blood · doi:10.1182/blood-2011-10-388298 · Cited by 299
Turner, J. J., Morton, L. M., Linet, M. S., Clarke, C. A., Kadin, M. E., Vajdic, C. M., Monnereau, A., Maynadié, M., Chiu, B. C.-H., Marcos-Gragera, R., et al. (2010) · Blood · doi:10.1182/blood-2010-06-289561 · Cited by 231
The European Hematology Association Roadmap for European Hematology Research: a consensus document
Engert, A., Balduini, C., Brand, A., Coiffier, B., Cordonnier, C., Dohner, H., de Wit, T. D., Eichinger, S., Fibbe, W., Green, T., et al. (2016) · Haematologica · doi:10.3324/haematol.2015.136739 · Cited by 81
“The German Low Grade Lymphoma Study Group established an MIPI that consists of age, lactate dehydrogenase level, white blood cell count, and performance status.(84) This index has been accepted worldwide as a tool to discriminate between different outcomes.”
BackgroundMethod
Metadata
- Authors
- Hoster, E., Dreyling, M., Klapper, W., Gisselbrecht, C., van Hoof, A., Kluin-Nelemans, H. C., Pfreundschuh, M., Reiser, M., Metzner, B., Einsele, H., Peter, N., Jung, W., Wörmann, B., Ludwig, W.-D., Dührsen, U., Eimermacher, H., Wandt, H., Hasford, J., Hiddemann, W., & Unterhalt, M.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2008-01-15
- Volume
- 111
- Issue
- 2
- Pages
- 558-565
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2130669641
- Cited by
- 984
- References
- 4
- FWCI
- 23.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma. https://app.cochat.ai/papers/10.1182/blood-2007-06-095331
- The paper
- Hoster, E., Dreyling, M., Klapper, W., Gisselbrecht, C., van Hoof, A., Kluin-Nelemans, H. C., Pfreundschuh, M., Reiser, M., Metzner, B., Einsele, H., Peter, N., Jung, W., Wörmann, B., Ludwig, W.-D., Dührsen, U., Eimermacher, H., Wandt, H., Hasford, J., Hiddemann, W., & Unterhalt, M. (2008). A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma. Blood. https://doi.org/10.1182/blood-2007-06-095331
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