The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin
Open accessAbstract
Tight regulation of the balance between apoptosis and survival is essential in angiogenesis. The ETS transcription factor Erg is required for endothelial tube formation in vitro. Inhibition of Erg expression in human umbilical vein endothelial cells (HUVECs), using antisense oligonucleotides, resulted in detachment of cell-cell contacts and increased cell death. Inhibition of Erg expression by antisense in HUVECs also lowered expression of the adhesion molecule vascular endothelial (VE)–cadherin, a key regulator of endothelial intercellular junctions and survival. Using chromatin immunoprecipitation, we showed that Erg binds to the VE-cadherin promoter. Furthermore, Erg was found to enhance VE-cadherin promoter activity in a transactivation assay. Apoptosis induced by inhibition of Erg was partly rescued by overexpression of VE-cadherin–GFP, suggesting that VE-cadherin is involved in the Erg-dependent survival signals. To show the role of Erg in angiogenesis in vivo, we used siRNA against Erg in a Matrigel plug model. Erg inhibition resulted in a significant decrease in vascularization, with increase in caspase-positive endothelial cells (ECs). These results identify a new pathway regulating angiogenesis and endothelial survival, via the transcription factor Erg and the adhesion molecule VE-cadherin.
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Cites
Hollenhorst, P. C. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh906 · Cited by 214
Cited by
Dejana, E., Tournier-Lasserve, E., & Weinstein, B. M. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.004 · Cited by 788
Self-citationZO-1 controls endothelial adherens junctions, cell–cell tension, angiogenesis, and barrier formation
Tornavaca, O., Chia, M., Dufton, N., Almagro, L. O., Conway, D. E., Randi, A. M., Schwartz, M. A., Matter, K., & Balda, M. S. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201404140 · Cited by 585
Self-citationTranscriptional Control of Endothelial Cell Development
De Val, S., & Black, B. L. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.014 · Cited by 346
“Knockdown of either Ets1 or Erg expression in endothelial cells in culture results in decreased endothelial cell migration and tube formation (Birdsey et al., 2008; Iwasaka et al., 1996).”
BackgroundKalna, V., Yang, Y., Peghaire, C. R., Frudd, K., Hannah, R., Shah, A. V., Osuna Almagro, L., Boyle, J. J., Göttgens, B., Ferrer, J., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.313788 · Cited by 119
Self-citationE-selectin in vascular pathophysiology
Zhang, J., Huang, S., Zhu, Z., Gatt, A., & Liu, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1401399 · Cited by 79
Metadata
- Authors
- Birdsey, G. M., Dryden, N. H., Amsellem, V., Gebhardt, F., Sahnan, K., Haskard, D. O., Dejana, E., Mason, J. C., & Randi, A. M.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2008-04-01
- Volume
- 111
- Issue
- 7
- Pages
- 3498-3506
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2099436620
- Cited by
- 268
- References
- 1
- FWCI
- 7.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Birdsey, G. M., Dryden, N. H., Amsellem, V., Gebhardt, F., Sahnan, K., Haskard, D. O., Dejana, E., Mason, J. C., & Randi, A. M. (2008). Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin. Blood. https://doi.org/10.1182/blood-2007-08-105346
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