The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Bleeding risk and the management of bleeding complications in patients undergoing anticoagulant therapy: focus on new anticoagulant agents
Abstract
For more than 60 years, heparin and coumarin have been mainstays of anticoagulation therapy. They are widely available, inexpensive, effective, and have specific antidotes but are regarded as problematic because of their need for careful monitoring. In addition, coumarin has a delayed onset of action, interacts with many medications, has a narrow therapeutic window, and is paradoxically prothrombotic in certain settings (ie, can precipitate “coumarin necrosis”). Heparin may require monitoring of its therapeutic effect and can also cause thrombosis (heparin-induced thrombocytopenia/thrombosis syndrome). These limitations have led to the development of new anticoagulants with the potential to replace current agents. These newer agents fall into 2 classes, based on whether they are antithrombin dependent (low-molecular-weight heparin, fondaparinux) or antithrombin independent (direct inhibitors of factor Xa and thrombin [factor IIa]). This paper addresses newer anticoagulants, reviewing their efficacy and limitations, and focuses on the risk of major bleeding that may complicate their use. In contrast to heparin and coumarin, none of these newer agents has a specific antidote that completely reverses its anticoagulant effect. Available data on the efficacy and safety of current and experimental agents for anticoagulant reversal are reviewed, and a plan for management of anticoagulant-induced bleeding is presented.
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Writing Committee Members, Antman, E. M., Anbe, D. T., Armstrong, P. W., Bates, E. R., Green, L. A., Hand, M., Hochman, J. S., Krumholz, H. M., Kushner, F. G., et al. (2004) · Circulation · doi:10.1161/01.cir.0000134791.68010.fa · Cited by 8,356
Prevention of Venous Thromboembolism
Geerts, W. H., Pineo, G. F., Heit, J. A., Bergqvist, D., Lassen, M. R., Colwell, C. W., & Ray, J. G. (2004) · Chest · doi:10.1378/chest.126.3_suppl.338s · Cited by 5,895
Braunwald, E., Antman, E. M., Beasley, J. W., Califf, R. M., Cheitlin, M. D., Hochman, J. S., Jones, R. H., Kereiakes, D., Kupersmith, J., Levin, T. N., et al. (2000) · Circulation · doi:10.1161/01.cir.102.10.1193 · Cited by 4,487
Making health care safer: a critical analysis of patient safety practices.
Shojania, K. G., Duncan, B. W., McDonald, K. M., Wachter, R. M., & Markowitz, A. J. (2001) · PubMed Central · Cited by 1,612
ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction
Antman, E. M., Anbe, D. T., Armstrong, P. W., Bates, E. R., Green, L. A., Hand, M., Hochman, J. S., Krumholz, H. M., Kushner, F. G., Lamas, G. A., et al. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.07.014 · Cited by 1,302
Antithrombotic Therapy for Venous Thromboembolic Disease
Büller, H. R., Agnelli, G., Hull, R. D., Hyers, T. M., Prins, M. H., & Raskob, G. E. (2004) · Chest · doi:10.1378/chest.126.3_suppl.401s · Cited by 1,249 · cited 2×
“As a result, we present the results of a narrative review designed to evaluate the following 2 questions: (1) What are the risks of bleeding associated with current and future anticoagulants? (2) Can evidence-based recommendations be provided for the management of bleeding in patients receiving anticoagulants?”
BackgroundInfluentialComparison of Fondaparinux and Enoxaparin in Acute Coronary Syndromes
(2006) · New England Journal of Medicine · doi:10.1056/nejmoa055443 · Cited by 1,228
Recombinant Activated Factor VII for Acute Intracerebral Hemorrhage
Mayer, S. A., Brun, N. C., Begtrup, K., Broderick, J., Davis, S., Diringer, M. N., Skolnick, B. E., & Steiner, T. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042991 · Cited by 1,167
Braunwald, E., Antman, E. M., Beasley, J. W., Califf, R. M., Cheitlin, M. D., Hochman, J. S., Jones, R. H., Kereiakes, D., Kupersmith, J., Levin, T. N., et al. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02336-7 · Cited by 1,116
Recombinant Activated Factor VII for Acute Intracerebral Hemorrhage
Mayer, S. A. (2007) · Stroke · doi:10.1161/01.str.0000254499.46122.22 · Cited by 1,034
Cited by
Stangier, J., Haertter, S., Liesenfeld, K.-H., Wienen, W., Feuring, M., Clemens, A., & Ryn, J. V. (2010) · Thrombosis and Haemostasis · doi:10.1160/th09-11-0758 · Cited by 1,382
Anticoagulation Drug Therapy: A Review
Harter, K., Levine, M., & Henderson, S. (2015) · Western Journal of Emergency Medicine · doi:10.5811/westjem.2014.12.22933 · Cited by 257
Metadata
- Authors
- Crowther, M. A., & Warkentin, T. E.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2008-05-15
- Volume
- 111
- Issue
- 10
- Pages
- 4871-4879
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1990134290
- Cited by
- 314
- References
- 58
- FWCI
- 12.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Crowther, M. A., & Warkentin, T. E. (2008). Bleeding risk and the management of bleeding complications in patients undergoing anticoagulant therapy: focus on new anticoagulant agents. Blood. https://doi.org/10.1182/blood-2007-10-120543
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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