The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease
Open accessAbstract
Th17 is a newly identified T-cell lineage that secretes proinflammatory cytokine IL-17. Th17 cells have been shown to play a critical role in mediating autoimmune diseases such as EAE, colitis, and arthritis, but their role in the pathogenesis of graft-versus-host disease (GVHD) is still unknown. Here we showed that, in an acute GVHD model of C57BL/6 (H-2b) donor to BALB/c (H-2d) recipient, IL-17−/− donor T cells manifested an augmented Th1 differentiation and IFN-γ production and induced exacerbated acute GVHD. Severe tissue damage mediated by IL-17−/− donor T cells was associated with increased Th1 infiltration, up-regulation of chemokine receptors by donor T cells, and enhanced tissue expression of inflammatory chemokines. Administration of recombinant IL-17 and neutralizing IFN-γ in the recipients given IL-17−/− donor cells ameliorated the acute GVHD. Furthermore, the regulation of Th1 differentiation by IL-17 or Th17 may be through its influence on host DCs. Our results indicate that donor Th17 cells can down-regulate Th1 differentiation and ameliorate acute GVHD in allogeneic recipients, and that treatments neutralizing proinflammatory cytokine IL-17 may augment acute GVHD as well as other inflammatory autoimmune diseases.
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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
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Transforming growth factor-β induces development of the TH17 lineage
Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087
IL-17 family cytokines and the expanding diversity of effector T cell lineages
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IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
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Requirement of Interleukin‐17A for Systemic Anti– Candida albicans Host Defense in Mice
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Cited by
Functional Specialization of Interleukin-17 Family Members
Iwakura, Y., Ishigame, H., Saijo, S., & Nakae, S. (2011) · Immunity · doi:10.1016/j.immuni.2011.02.012 · Cited by 1,289
Cooke, K. R., Luznik, L., Sarantopoulos, S., Hakim, F. T., Jagasia, M., Fowler, D. H., van den Brink, M. R. M., Hansen, J. A., Parkman, R., Miklos, D. B., et al. (2017) · Biology of Blood and Marrow Transplantation · doi:10.1016/j.bbmt.2016.09.023 · Cited by 472
Laurence, A., Amarnath, S., Mariotti, J., Kim, Y. C., Foley, J., Eckhaus, M., O'Shea, J. J., & Fowler, D. H. (2012) · Immunity · doi:10.1016/j.immuni.2012.05.027 · Cited by 201
Metadata
- Authors
- Yi, T., Zhao, D., Lin, C.-L., Zhang, C., Chen, Y., Todorov, I., LeBon, T., Kandeel, F., Forman, S., & Zeng, D.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2008-09-01
- Volume
- 112
- Issue
- 5
- Pages
- 2101-2110
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2082832770
- Cited by
- 207
- References
- 12
- FWCI
- 14.88
- Type
- journal article
- Language
- en
- Open access
- green
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- Yi, T., Zhao, D., Lin, C.-L., Zhang, C., Chen, Y., Todorov, I., LeBon, T., Kandeel, F., Forman, S., & Zeng, D. (2008). Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease. Blood. https://doi.org/10.1182/blood-2007-12-126987
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