The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell–depleting therapy with rituximab
Abstract
The effects of B-cell depletion with rituximab on regulatory T cells (Tregs) have not been determined. We investigated Tregs in patients receiving rituximab for chronic idiopathic thrombocytopenic purpura (ITP). The peripheral blood Tregs, identified as CD4+FOXP3+ T cells, were measured by flow cytometry prior to and after the immunotherapy. In addition, Tregs were analyzed for their usage of the T-cell receptor (TCR) β-variable (VB) region gene as well as their regulatory function as assessed by cell proliferation assays. Pretreatment data revealed a reduced number and a defective suppressive capacity of Tregs in ITP patients compared with control individuals. In addition, Tregs showed a polyclonal spectratype. Patients, particularly responders, showed restored numbers of Tregs as well as a restored regulatory function upon treatment with rituximab. These results indicate that patients with active ITP have a defective T regulatory cell compartment that can be modulated by a B cell–targeted therapy.
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Citations
Cites
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
Cited by
Pathogenesis and Therapeutic Mechanisms in Immune Thrombocytopenia (ITP)
Zufferey, A., Kapur, R., & Semple, J. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6020016 · Cited by 566
Cooper, N., & Ghanima, W. (2019) · New England Journal of Medicine · doi:10.1056/nejmcp1810479 · Cited by 503
Self-citationIijima, K., Sako, M., Nozu, K., Mori, R., Tuchida, N., Kamei, K., Miura, K., Aya, K., Nakanishi, K., Ohtomo, Y., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60541-9 · Cited by 451
Pathogenesis of immune thrombocytopenia
Audia, S., Mahévas, M., Samson, M., Godeau, B., & Bonnotte, B. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.04.012 · Cited by 395
Bao, W., Bussel, J. B., Heck, S., He, W., Karpoff, M., Boulad, N., & Yazdanbakhsh, K. (2010) · Blood · doi:10.1182/blood-2010-04-281717 · Cited by 345
Metadata
- Authors
- Stasi, R., Cooper, N., Del Poeta, G., Stipa, E., Laura Evangelista, M., Abruzzese, E., & Amadori, S.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2008-08-15
- Volume
- 112
- Issue
- 4
- Pages
- 1147-1150
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1975300245
- Cited by
- 410
- References
- 1
- FWCI
- 17.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell–depleting therapy with rituximab. https://app.cochat.ai/papers/10.1182/blood-2007-12-129262
- The paper
- Stasi, R., Cooper, N., Del Poeta, G., Stipa, E., Laura Evangelista, M., Abruzzese, E., & Amadori, S. (2008). Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell–depleting therapy with rituximab. Blood. https://doi.org/10.1182/blood-2007-12-129262
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
