The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
Translation of the Philadelphia chromosome into therapy for CML
Abstract
Throughout its history, chronic myeloid leukemia (CML) has set precedents for cancer research and therapy. These range from the identification of the first specific chromosomal abnormality associated with cancer to the development of imatinib as a specific, targeted therapy for the disease. The successful development of imatinib as a therapeutic agent for CML can be attributed directly to decades of scientific discoveries. These discoveries determined that the BCR-ABL tyrosine kinase is the critical pathogenetic event in CML and an ideal target for therapy. This was confirmed in clinical trials of imatinib, with imatinib significantly improving the long-term survival of patients with CML. Continuing in this tradition of scientific discoveries leading to improved therapies, the understanding of resistance to imatinib has rapidly led to strategies to circumvent resistance. Continued studies of hematologic malignancies will allow this paradigm of targeting molecular pathogenetic events to be applied to many additional hematologic cancers.
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1 retracted
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Self-citationFive-Year Follow-up of Patients Receiving Imatinib for Chronic Myeloid Leukemia
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Self-citationClinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or Amplification
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Self-citationA minute chromosome in human chronic granulocytic leukemia
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Self-citation
Cited by
Bendall, S. C., Simonds, E. F., Qiu, P., Amir, E.-A. D., Krutzik, P. O., Finck, R., Bruggner, R. V., Melamed, R., Trejo, A., Ornatsky, O. I., et al. (2011) · Science · doi:10.1126/science.1198704 · Cited by 2,279
Tyrosine phosphorylation: thirty years and counting
Hunter, T. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.01.028 · Cited by 658
Drug development in the era of precision medicine
Dugger, S. A., Platt, A., & Goldstein, D. B. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.226 · Cited by 493
Differentiation therapy of leukemia: 3 decades of development.
Nowak, D., Stewart, D., & Koeffler, H. P. (2009) · Blood · doi:10.1182/blood-2009-01-198911 · Cited by 348
Passenger deletions generate therapeutic vulnerabilities in cancer
Muller, F. L., Colla, S., Aquilanti, E., Manzo, V. E., Genovese, G., Lee, J., Eisenson, D., Narurkar, R., Deng, P., Nezi, L., et al. (2012) · Nature · doi:10.1038/nature11331 · Cited by 339
Metadata
- Authors
- Druker, B. J.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2008-12-15
- Volume
- 112
- Issue
- 13
- Pages
- 4808-4817
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2076500257
- Cited by
- 668
- References
- 90
- FWCI
- 35.49
- Type
- journal article
- Language
- en
- Open access
- closed
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