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Dual NAMPT and BTK Targeting Leads to Synergistic Killing of Waldenström Macroglobulinemia Cells Regardless of MYD88 and CXCR4 Somatic Mutation Status

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EWS-FLI1 confers exquisite sensitivity to NAMPT inhibition in Ewing sarcoma cells

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Dual nicotinamide phosphoribosyltransferase and epidermal growth factor receptor inhibitors for the treatment of cancer

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Structure-Based Design of Potent Nicotinamide Phosphoribosyltransferase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities

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Inhibition of NAMPT sensitizes MOLT4 leukemia cells for etoposide treatment through the SIRT2-p53 pathway

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[18F]FLT and [18F]FDG PET for Non-invasive Treatment Monitoring of the Nicotinamide Phosphoribosyltransferase Inhibitor APO866 in Human Xenografts

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Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent

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Nicotinamide mononucleotide ameliorates senescence in alveolar epithelial cells

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FK866 attenuates acute hepatic failure through c-jun-N-terminal kinase (JNK)-dependent autophagy

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Pancreatic Cancer Metabolism: Molecular Mechanisms and Clinical Applications

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Combinative effects of β-Lapachone and APO866 on pancreatic cancer cell death through reactive oxygen species production and PARP-1 activation

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Secretion of One Adipokine Nampt/Visfatin Suppresses the Inflammatory Stress‐Induced NF‐κB Activity and Affects Nampt‐Dependent Cell Viability in Huh‐7 Cells

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The regulatory relationship between NAMPT and PD-L1 in cancer and identification of a dual-targeting inhibitor

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The Role of Nicotinamide Phosphoribosyltransferase in Cerebral Ischemia

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The Use of Carboranes in Cancer Drug Development

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Visfatin and Rheumatoid Arthritis: Pathogenetic Implications and Clinical Utility

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Chimeric kinase ALK induces expression of NAMPT and selectively depends on this metabolic enzyme to sustain its own oncogenic function

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Monosomy 7/del(7q) cause sensitivity to inhibitors of nicotinamide phosphoribosyltransferase in acute myeloid leukemia

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SIRT1 and HSP90α feed-forward circuit safeguards chromosome segregation integrity in diffuse large B cell lymphomas

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Where can biology of childhood ALL be attacked by new compounds?

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Distinct Capabilities in NAD Metabolism Mediate Resistance to NAMPT Inhibition in Glioblastoma

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Clickable prodrugs bearing potent and hydrolytically cleavable nicotinamide phosphoribosyltransferase inhibitors

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Serum Adipocytokines (Visfatin and Resistin): New Biomarkers of Breast Carcinogenesis

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MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma

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Analysis of CCND3 mutations in diffuse large B-cell lymphoma

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Nicotinaldehyde, a Novel Precursor of NAD Biosynthesis, Abrogates the Anti-Cancer Activity of an NAD-Lowering Agent in Leukemia

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Visfatin promotes the malignancy of human acute myeloid leukemia cells via regulation of IL-17

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Development of a cuproptosis-related prognostic signature to reveal heterogeneity of the immune microenvironment and drug sensitivity in acute lymphoblastic leukemia

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Wisfatyna — enzym, cytokina czy adipokina? Funkcje biologiczne wisfatyny in vitro

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Metabolic reprogramming of myeloid cells in cancer: from lactate–NAMPT axis to AI-guided therapeutics

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Repurposing NAMPT Inhibitors for Germinal Center B Cell–Like Diffuse Large B-Cell Lymphoma

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NAPRT Expression and Epigenetic Regulation in Pediatric Rhabdomyosarcoma as a Potential Biomarker for NAMPT Inhibition

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Efficacy of NAMPT inhibition in T-cell acute lymphoblastic leukemia

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The Roles of Moonlighting Nicotinamide Mononucleotide Adenylyl Transferases in Cell Physiology

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Inhibiting Nampt signaling promotes M2 macrophage polarization to enhance bone regeneration in periodontitis

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Nicotinamide Phosphoribosyltransferase Inhibitors

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Evaluating the anti-leukemia activity of avocatin B

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NQO1 Bioactivatable Drugs Enhance Radiation Responses

Bey, E. A., Meade, J. C., Silvers, M. A., Motea, E. A., Patidar, P. L., Brekken, R. A., Deja, S., Merritt, M. E., Kilgore, J. A., Liu, Y., et al. (2016) · Springer eBooks · doi:10.1007/978-3-319-45594-5_10

mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition

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Peer Review #2 of "Relationship between triterpenoid anticancer drug resistance, autophagy, and caspase-1 in adult T-cell leukemia (v0.1)"

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Peer Review #1 of "Relationship between triterpenoid anticancer drug resistance, autophagy, and caspase-1 in adult T-cell leukemia (v0.2)"

(2016) · PeerJ · doi:10.7287/peerj.2026v0.2/reviews/1

Peer Review #1 of "Relationship between triterpenoid anticancer drug resistance, autophagy, and caspase-1 in adult T-cell leukemia (v0.1)"

(2016) · PeerJ · doi:10.7287/peerj.2026v0.1/reviews/1

Data from High Visfatin Expression in Breast Cancer Tissue Is Associated with Poor Survival

Lee, Y., Yang, Y., Su, J., Chang, H., Hou, M., & Yuan, S. F. (2023) · doi:10.1158/1055-9965.c.6514897

Data from High Visfatin Expression in Breast Cancer Tissue Is Associated with Poor Survival

Lee, Y., Yang, Y., Su, J., Chang, H., Hou, M., & Yuan, S. F. (2023) · doi:10.1158/1055-9965.c.6514897.v1

Data from Dual NAMPT and BTK Targeting Leads to Synergistic Killing of Waldenström Macroglobulinemia Cells Regardless of MYD88 and CXCR4 Somatic Mutation Status

Cea, M., Cagnetta, A., Acharya, C., Acharya, P. C., Tai, Y., Cao, Y., Lovera, D., Soncini, D., Miglino, M., Orcioni, G. F., et al. (2023) · doi:10.1158/1078-0432.c.6526731.v1

Identification and validation of drugs for repurposing in Glioblastoma: a computational and experimental workflowPreprint

González, N., Küper, M. P., Fallit, M. G., Agudelo, J. A. P., Candia, A. J. N., Velandia, M. S., Videla-Richardson, G. A., & Candolfi, M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.29.589520

NAMPT haploinsufficiency is a therapeutic vulnerability to NAMPT inhibition in -7/-7q MDSPreprint

Ikonen, N., Ruokoranta, T. M., Hyyppa, S., Sinervuori, E., Miettinen, J. J., Saad, J. J., Vähä-Koskela, M. J. V., & Heckman, C. A. (2025) · medRxiv · doi:10.1101/2025.09.14.25335622

In the diffuse large B-cell lymphoma microenvironment, SIRT1 is upregulated and correlated with a pro-inflammatory macrophage signature and autophagy-related gene expression

Resanoa, M., Azcoaga, P., Salvador, N., Delgado, A., Rodiño, C., Schoenhals, M. J., & Braza, M. S. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1701514

Pyrimidine and NAD salvage pathways : unexpected allies in the maintenance of genome stability

Silveira, S. C. (2018) · theses.fr (ABES) · doi:10.70675/d8951764z7ae2z4d5eza2e1z0b24bea9f901

Etude in vivo du rôle du métabolisme énergétique et mitochondrial dans la résistance thérapeutique des leucémies aiguës myéloïdes

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Physicochemical and Metabolic Optimization of NAMPT Inhibitors Enables Effective Antibody–Drug Conjugates for Liquid and Solid Tumors

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A context-dependent framework for targeting NAD metabolism in cancer

Arrizabalaga, L., Santambrogio, L., Kroemer, G., Galluzzi, L., & Buqué, A. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.09.015

BindingDB Entry 50009816: Structure-Based Design of Potent Nicotinamide Phosphoribosyltransferase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities.

BindingDB (2021) · UC San Diego · doi:10.7270/q2qz2ffr

BindingDB Entry 50043627: Nicotinamide phosphoribosyltransferase inhibitors, design, preparation, and structure-activity relationship.

BindingDB (2014) · UC San Diego · doi:10.7270/q2cv4k6w

BindingDB Entry 50008800: Discovery of trans-3-(pyridin-3-yl)acrylamide-derived sulfamides as potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitors for the potential treatment of cancer.

BindingDB (2021) · UC San Diego · doi:10.7270/q2862kv5

BindingDB Entry 50013817: Dual nicotinamide phosphoribosyltransferase and epidermal growth factor receptor inhibitors for the treatment of cancer.

BindingDB (2022) · UC San Diego · doi:10.7270/q2r49vjr

BindingDB Entry 50000142: Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors.

BindingDB (2019) · UC San Diego · doi:10.7270/q2vm4fdv

BindingDB Entry 50043350: Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors.

BindingDB (2014) · UC San Diego · doi:10.7270/q25q4xj8

BindingDB Entry 50019578: Synthesis and structure-activity relationship of new nicotinamide phosphoribosyltransferase inhibitors with antitumor activity on solid and haematological cancer.

BindingDB (2024) · UC San Diego · doi:10.7270/q2q244m2

Abstract 1462: Targeting NAD+ biosynthesis combined with radiation to enhance cell death

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A critical role of autophagy in antileukemia/lymphoma effects of APO866, an inhibitor of NAD biosynthesis

Ginet, V., Puyal, J., Rummel, C., Aubry, D., Breton, C. S., Cloux, A.-J., Majjigapu, S. R., Sordat, B., Vogel, P., Bruzzone, S., et al. (2014) · Autophagy · doi:10.4161/auto.27722 · Cited by 38

Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent

Cloux, A.-J., Aubry, D., Heulot, M., Widmann, C., ElMokh, O., Piacente, F., Cea, M., Nencioni, A., Bellotti, A., Bouzourène, K., et al. (2019) · Oncotarget · doi:10.18632/oncotarget.27336 · Cited by 23

Response: NAD targeting efficiently kills hematologic cancer cells

Nahimana, A., Aubry, D., Butcher, S., & Duchosal, M. A. (2009) · Blood · doi:10.1182/blood-2009-04-211243

Antitumor efficacy of APO866 against Myla-2059, a model of cutaneous t-cell lymphoma

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