The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome
Open accessAbstract
Mutations in CCAAT/enhancer binding protein α (CEBPA) are seen in 5% to 14% of acute myeloid leukemia (AML) and have been associated with a favorable clinical outcome. Most AMLs with CEBPA mutations simultaneously carry 2 mutations (CEBPAdouble-mut), usually biallelic, whereas single heterozygous mutations (CEBPAsingle-mut) are less frequently seen. Using denaturing high-performance liquid chromatography and nucleotide sequencing, we identified among a cohort of 598 newly diagnosed AMLs a subset of 41 CEBPA mutant cases (28 CEBPAdouble-mut and 13 CEBPAsingle-mut cases). CEBPAdouble-mut associated with a unique gene expression profile as well as favorable overall and event-free survival, retained in multivariable analysis that included cytogenetic risk, FLT3-ITD and NPM1 mutation, white blood cell count, and age. In contrast, CEBPAsingle-mut AMLs did not express a discriminating signature and could not be distinguished from wild-type cases as regards clinical outcome. These results demonstrate significant underlying heterogeneity within CEBPA mutation-positive AML with prognostic relevance.
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Cites
Diagnosis of multiple cancer types by shrunken centroids of gene expression
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Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia
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Self-citationFunctional genomic landscape of acute myeloid leukaemia
Tyner, J. W., Tognon, C. E., Bottomly, D., Wilmot, B., Kurtz, S. E., Savage, S. L., Long, N., Schultz, A. R., Traer, E., Abel, M., et al. (2018) · Nature · doi:10.1038/s41586-018-0623-z · Cited by 1,303
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Self-citationTherapeutic Advances in Acute Myeloid Leukemia
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Self-citation
Metadata
- Authors
- Wouters, B. J., Löwenberg, B., Erpelinck-Verschueren, C. A. J., van Putten, W. L. J., Valk, P. J. M., & Delwel, R.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2009-03-26
- Volume
- 113
- Issue
- 13
- Pages
- 3088-3091
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1965113891
- Cited by
- 566
- References
- 20
- FWCI
- 29.52
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome. https://app.cochat.ai/papers/10.1182/blood-2008-09-179895
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- Wouters, B. J., Löwenberg, B., Erpelinck-Verschueren, C. A. J., van Putten, W. L. J., Valk, P. J. M., & Delwel, R. (2009). Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome. Blood. https://doi.org/10.1182/blood-2008-09-179895
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